Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc
Many psychiatric disorders, despite their specific characteristics, share deficits in the cognitive domain including executive functions, emotional control and memory. However, memory deficits have been in many cases undervalued compared with other characteristics. The expression of Immediate Early...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00079/full |
| _version_ | 1819280640040763392 |
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| author | Francisco T. Gallo Cynthia Katche Juan F. Morici Jorge H. Medina Jorge H. Medina Noelia V. Weisstaub |
| author_facet | Francisco T. Gallo Cynthia Katche Juan F. Morici Jorge H. Medina Jorge H. Medina Noelia V. Weisstaub |
| author_sort | Francisco T. Gallo |
| collection | DOAJ |
| description | Many psychiatric disorders, despite their specific characteristics, share deficits in the cognitive domain including executive functions, emotional control and memory. However, memory deficits have been in many cases undervalued compared with other characteristics. The expression of Immediate Early Genes (IEGs) such as, c-fos, Egr1 and arc are selectively and promptly upregulated in learning and memory among neuronal subpopulations in regions associated with these processes. Changes in expression in these genes have been observed in recognition, working and fear related memories across the brain. Despite the enormous amount of data supporting changes in their expression during learning and memory and the importance of those cognitive processes in psychiatric conditions, there are very few studies analyzing the direct implication of the IEGs in mental illnesses. In this review, we discuss the role of some of the most relevant IEGs in relation with memory processes affected in psychiatric conditions. |
| first_indexed | 2024-12-24T00:47:00Z |
| format | Article |
| id | doaj.art-f48b2f34fb5c435bb09f7933c3ebbc8f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-24T00:47:00Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-f48b2f34fb5c435bb09f7933c3ebbc8f2022-12-21T17:23:47ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532018-04-011210.3389/fnbeh.2018.00079309251Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and ArcFrancisco T. Gallo0Cynthia Katche1Juan F. Morici2Jorge H. Medina3Jorge H. Medina4Noelia V. Weisstaub5Instituto de Fisiología y Biofísica Bernardo Houssay, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, ArgentinaInstituto de Biología Celular y Neurociencias (IBCN) Dr. Eduardo de Robertis, Facultad de Medicina, CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, ArgentinaInstituto de Fisiología y Biofísica Bernardo Houssay, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, ArgentinaInstituto de Biología Celular y Neurociencias (IBCN) Dr. Eduardo de Robertis, Facultad de Medicina, CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, ArgentinaDepartamento de Fisiología, Facultad de Medicina, Universidad de Buenos (UBA), Buenos Aires, ArgentinaInstituto de Fisiología y Biofísica Bernardo Houssay, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, ArgentinaMany psychiatric disorders, despite their specific characteristics, share deficits in the cognitive domain including executive functions, emotional control and memory. However, memory deficits have been in many cases undervalued compared with other characteristics. The expression of Immediate Early Genes (IEGs) such as, c-fos, Egr1 and arc are selectively and promptly upregulated in learning and memory among neuronal subpopulations in regions associated with these processes. Changes in expression in these genes have been observed in recognition, working and fear related memories across the brain. Despite the enormous amount of data supporting changes in their expression during learning and memory and the importance of those cognitive processes in psychiatric conditions, there are very few studies analyzing the direct implication of the IEGs in mental illnesses. In this review, we discuss the role of some of the most relevant IEGs in relation with memory processes affected in psychiatric conditions.http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00079/fullEgr1c-FosArcfear memoryepisodic memoryrodents |
| spellingShingle | Francisco T. Gallo Cynthia Katche Juan F. Morici Jorge H. Medina Jorge H. Medina Noelia V. Weisstaub Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc Frontiers in Behavioral Neuroscience Egr1 c-Fos Arc fear memory episodic memory rodents |
| title | Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc |
| title_full | Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc |
| title_fullStr | Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc |
| title_full_unstemmed | Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc |
| title_short | Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc |
| title_sort | immediate early genes memory and psychiatric disorders focus on c fos egr1 and arc |
| topic | Egr1 c-Fos Arc fear memory episodic memory rodents |
| url | http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00079/full |
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