Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes

Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes

Halogenation of bioactive peptides via incorporation of non-natural amino acid derivatives during chemical synthesis is a common strategy to enhance functionality. Bacterial tyrptophan halogenases efficiently catalyze regiospecific halogenation of the free amino acid tryptophan, both in vitro and in...

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Bibliographic Details
Main Authors: Barindra Sana, Ding Ke, Eunice Hui Yen Li, Timothy Ho, Jayasree Seayad, Hung A. Duong, Farid J. Ghadessy
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
halogenation
protein
peptide
PyrH
enzyme engineering
Online Access:https://www.mdpi.com/2218-273X/12/12/1841

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