Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling

Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling

Abstract Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant in clinics due to the poor understanding of the exact underlying mechanism. We previously...

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Bibliographic Details
Main Authors: Chuang Yuan, Kelong Ai, Menghua Xiang, Chengliang Xie, Mingyi Zhao, Ming Wu, Hongli Li, Yueren Wu, Yueqing Cao, Can Li, Yanjun Zhong, Xiaomeng Pei, Helen Ka Wai Law, Liqian Gao, Qicai Xiao, Xinyu Yang
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05151-7

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