Progesterone-Calcitriol Combination Enhanced Cytotoxicity of Cisplatin in Ovarian and Endometrial Cancer Cells In Vitro

Progesterone-Calcitriol Combination Enhanced Cytotoxicity of Cisplatin in Ovarian and Endometrial Cancer Cells In Vitro

Initially, patients that respond to cisplatin (DDP) treatment later relapse and develop chemoresistance. Agents that enhance DDP effectiveness will have a significant impact on cancer treatment. We have shown pronounced inhibitory effects of the progesterone-calcitriol combination on endometrial and...

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Bibliographic Details
Main Authors: Ana Paucarmayta, Hannah Taitz, Latoya McGlorthan, Yovanni Casablanca, G. Larry Maxwell, Kathleen M. Darcy, Viqar Syed
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomedicines
Subjects:
cisplatin
SMAD2/3
ABC transporters
gynecological cancer
multidrug resistance protein-1
Online Access:https://www.mdpi.com/2227-9059/8/4/73

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