Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia
BackgroundIt has been proven that the ratio of albumin to globulin (A/G) is a typical biomarker for monitoring inflammation and nutritional status. But the potential role of A/G in stroke-associated pneumonia (SAP) after acute ischemic stroke (AIS) remained unknown.Patients and methodsFollowing incl...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.970573/full |
| _version_ | 1798039961157500928 |
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| author | Lingli Chen Minjie Xu Qiqi Huang Yuntao Liu Wenwei Ren |
| author_facet | Lingli Chen Minjie Xu Qiqi Huang Yuntao Liu Wenwei Ren |
| author_sort | Lingli Chen |
| collection | DOAJ |
| description | BackgroundIt has been proven that the ratio of albumin to globulin (A/G) is a typical biomarker for monitoring inflammation and nutritional status. But the potential role of A/G in stroke-associated pneumonia (SAP) after acute ischemic stroke (AIS) remained unknown.Patients and methodsFollowing inclusion criteria, 5,173 AIS patients were included and segmented into SAP (n = 897) and non-SAP (n = 4,276) groups. The differences in variables between groups were compared. The logistic regression model was used to determine the association between A/G and SAP, and a forest plot was drawn.ResultsCompared with the non-SAP group, the SAP group had a lower A/G level (P < 0.001). Then, A/G was divided into quartiles. In comparison to Q3 (A/G = 1.25–1.39), logistic regression revealed that patients with a lower A/G (A/G ≤ 1.09) had a higher risk of SAP (OR = 1.96, 95% CI, 1.56–2.46, P < 0.001). On the contrary, those with a higher A/G (A/G ≥ 1.4) had a lower SAP risk (OR = 0.73, 95% CI, 0.54–0.97, P = 0.029).ConclusionThe study revealed that a low A/G level was associated with an increased SAP risk. Appropriate preventative measures for SAP should be taken in AIS patients with a low A/G level. |
| first_indexed | 2024-04-11T22:00:55Z |
| format | Article |
| id | doaj.art-f48d88bf7f484615a9b0b5b3a647a923 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T22:00:55Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-f48d88bf7f484615a9b0b5b3a647a9232022-12-22T04:00:56ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.970573970573Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumoniaLingli Chen0Minjie Xu1Qiqi Huang2Yuntao Liu3Wenwei Ren4Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundIt has been proven that the ratio of albumin to globulin (A/G) is a typical biomarker for monitoring inflammation and nutritional status. But the potential role of A/G in stroke-associated pneumonia (SAP) after acute ischemic stroke (AIS) remained unknown.Patients and methodsFollowing inclusion criteria, 5,173 AIS patients were included and segmented into SAP (n = 897) and non-SAP (n = 4,276) groups. The differences in variables between groups were compared. The logistic regression model was used to determine the association between A/G and SAP, and a forest plot was drawn.ResultsCompared with the non-SAP group, the SAP group had a lower A/G level (P < 0.001). Then, A/G was divided into quartiles. In comparison to Q3 (A/G = 1.25–1.39), logistic regression revealed that patients with a lower A/G (A/G ≤ 1.09) had a higher risk of SAP (OR = 1.96, 95% CI, 1.56–2.46, P < 0.001). On the contrary, those with a higher A/G (A/G ≥ 1.4) had a lower SAP risk (OR = 0.73, 95% CI, 0.54–0.97, P = 0.029).ConclusionThe study revealed that a low A/G level was associated with an increased SAP risk. Appropriate preventative measures for SAP should be taken in AIS patients with a low A/G level.https://www.frontiersin.org/articles/10.3389/fnut.2022.970573/fullalbumin to globulinacute ischemic strokepneumoniapredictriskratio |
| spellingShingle | Lingli Chen Minjie Xu Qiqi Huang Yuntao Liu Wenwei Ren Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia Frontiers in Nutrition albumin to globulin acute ischemic stroke pneumonia predict risk ratio |
| title | Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia |
| title_full | Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia |
| title_fullStr | Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia |
| title_full_unstemmed | Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia |
| title_short | Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia |
| title_sort | clinical significance of albumin to globulin ratio among patients with stroke associated pneumonia |
| topic | albumin to globulin acute ischemic stroke pneumonia predict risk ratio |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.970573/full |
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