Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer
Introduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery.Methods: Th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1194398/full |
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| author | Yanfen Zheng Yanfen Zheng Zhiguo Li Chuyi Liu Xiaotong Fan Zheng Luo Zheng Luo Zibiao Li Zibiao Li Zibiao Li Yun-Long Wu |
| author_facet | Yanfen Zheng Yanfen Zheng Zhiguo Li Chuyi Liu Xiaotong Fan Zheng Luo Zheng Luo Zibiao Li Zibiao Li Zibiao Li Yun-Long Wu |
| author_sort | Yanfen Zheng |
| collection | DOAJ |
| description | Introduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery.Methods: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The catalytic activity, ROS scavenge and oxygen supply ability of GCN was validated. The therapeutic effect of GCN was verified in the diabetic gingival ulcer model.Results: The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis.Discussion: This multifunctional GCN with ROS depletion, continuous oxygen supply and good biocompatibility, which might provide a novel therapeutic strategy for effective treatment of diabetic oral mucosa ulcers. |
| first_indexed | 2024-03-13T10:02:45Z |
| format | Article |
| id | doaj.art-f48fee406ff64590be36d6554ed7de7e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T10:02:45Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f48fee406ff64590be36d6554ed7de7e2023-05-23T04:45:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-05-011110.3389/fbioe.2023.11943981194398Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcerYanfen Zheng0Yanfen Zheng1Zhiguo Li2Chuyi Liu3Xiaotong Fan4Zheng Luo5Zheng Luo6Zibiao Li7Zibiao Li8Zibiao Li9Yun-Long Wu10Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, Fujian, ChinaChina and Fujian College Engineering Research Center for Dental Biomaterials, Xiamen, ChinaFujian Provincial Key Laboratory of Innovative Drug Target Research, State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Innovative Drug Target Research, State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeFujian Provincial Key Laboratory of Innovative Drug Target Research, State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Materials Science and Engineering, National University of Singapore, Singapore, SingaporeFujian Provincial Key Laboratory of Innovative Drug Target Research, State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaIntroduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery.Methods: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The catalytic activity, ROS scavenge and oxygen supply ability of GCN was validated. The therapeutic effect of GCN was verified in the diabetic gingival ulcer model.Results: The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis.Discussion: This multifunctional GCN with ROS depletion, continuous oxygen supply and good biocompatibility, which might provide a novel therapeutic strategy for effective treatment of diabetic oral mucosa ulcers.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1194398/fullnanogelbiomaterialsmucosa ulcerationnanoenzymewound healing |
| spellingShingle | Yanfen Zheng Yanfen Zheng Zhiguo Li Chuyi Liu Xiaotong Fan Zheng Luo Zheng Luo Zibiao Li Zibiao Li Zibiao Li Yun-Long Wu Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer Frontiers in Bioengineering and Biotechnology nanogel biomaterials mucosa ulceration nanoenzyme wound healing |
| title | Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| title_full | Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| title_fullStr | Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| title_full_unstemmed | Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| title_short | Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| title_sort | multi functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer |
| topic | nanogel biomaterials mucosa ulceration nanoenzyme wound healing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1194398/full |
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