Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected...
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MDPI AG
2022-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/10/1270 |
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| author | Tengfei Yu Rong Wang Xun Ye Chun Zeng Xiaolin Chen Yuanli Zhao |
| author_facet | Tengfei Yu Rong Wang Xun Ye Chun Zeng Xiaolin Chen Yuanli Zhao |
| author_sort | Tengfei Yu |
| collection | DOAJ |
| description | Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; <i>p</i> = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; <i>p</i> = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; <i>p</i> = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; <i>p</i> = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; <i>p</i> = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; <i>p</i> = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; <i>p</i> = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD. |
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| format | Article |
| id | doaj.art-f4943da42fe342cc8291b63540541041 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:35:30Z |
| publishDate | 2022-09-01 |
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| series | Brain Sciences |
| spelling | doaj.art-f4943da42fe342cc8291b635405410412023-11-23T23:12:44ZengMDPI AGBrain Sciences2076-34252022-09-011210127010.3390/brainsci12101270Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya DiseaseTengfei Yu0Rong Wang1Xun Ye2Chun Zeng3Xiaolin Chen4Yuanli Zhao5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, ChinaObjective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; <i>p</i> = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; <i>p</i> = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; <i>p</i> = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; <i>p</i> = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; <i>p</i> = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; <i>p</i> = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; <i>p</i> = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD.https://www.mdpi.com/2076-3425/12/10/1270moyamoya diseaseangioarchitectural factorDSAdirect and indirect revascularizationpostoperative cerebral infarction |
| spellingShingle | Tengfei Yu Rong Wang Xun Ye Chun Zeng Xiaolin Chen Yuanli Zhao Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease Brain Sciences moyamoya disease angioarchitectural factor DSA direct and indirect revascularization postoperative cerebral infarction |
| title | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
| title_full | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
| title_fullStr | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
| title_full_unstemmed | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
| title_short | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
| title_sort | angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease |
| topic | moyamoya disease angioarchitectural factor DSA direct and indirect revascularization postoperative cerebral infarction |
| url | https://www.mdpi.com/2076-3425/12/10/1270 |
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