Prognostic Significance of the New Prostatic Carcinoma Grade Grouping System vis-àvis Biochemical Recurrence: Experience from a Tertiary Care Centre in Dakshina Kannada District, Karnataka, India
Introduction: Prostate cancer is the second leading malignancy in males worldwide, with a similar preponderance being seen in India. Universally, Prostate Specific Antigen (PSA) is a widely utilised resourceful screening and prognostic marker; however, few patients still present in advanced stag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-07-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2510/49222_CE[Ra1]_F(SHU)_PF1(AB_SL)_PFA(AB_KM)_PN(KM).pdf |
| Summary: | Introduction: Prostate cancer is the second leading malignancy
in males worldwide, with a similar preponderance being seen in
India. Universally, Prostate Specific Antigen (PSA) is a widely
utilised resourceful screening and prognostic marker; however,
few patients still present in advanced stage. Hence, it is crucial
to recognise the risk groups with utility of different prognostic
parameters like Gleason grade grouping apart from PSA level.
Studies have validated the Grade Group (GG) as prognostic
marker for Biochemical Recurrence (BR) as well as diseasespecific death of patients.
Aim: To assess the usefulness of the new prostatic GG
system as compared to the earlier Gleasons scoring system in
prognostication, with the post therapy PSA levels being utilised
as evidence of BR.
Materials and Methods: This was a retrospective study
conducted on cases received over a duration of three years
from January 2017 to December 2019 in the Department of
Pathology Yenepoya Medical College, Mangalore. All the
prostatic carcinoma slides were reviewed and reported by
histopathologists according to modified grade grouping system
and College of American Pathologists protocol. All parameters
were analysed in SPSS software version 23.
Results: A total 72 cases (23 prostatectomy and 49 biopsy
samples) were included. Majority of prostatectomy cases
presented in T3b TNM stage and showed perineural invasion.
Significant relationship was found between old Gleason’s
Scoring (GS) system and new grade grouping with p-value of
0.05. Regression analysis reveals new GG is 15 times better
than old GS reporting.
Conclusion: The new grade grouping of prostatic
adenocarcinoma is better than GS system in prognostication
and compares well with TNM staging and perineural
invasion. |
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| ISSN: | 2277-8551 2455-6882 |