Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review
Low-grade adenosquamous carcinoma (LGASC) is a rare invasive tumor that occurs in breast parenchyma. It has previously only been reported in females. Herein, we describe the case of a 52-year-old male who presented with a palpable mass in his right axilla that he reported had been present for 20-yea...
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| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.01714/full |
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| author | Xingqiang Yan Fanshuang Zhu Qiupeng Wang Lijie Chen Yixing Zhou Zenggui Wu Linhang Mei Zhaosheng Ma Binbin Cui Feilin Cao |
| author_facet | Xingqiang Yan Fanshuang Zhu Qiupeng Wang Lijie Chen Yixing Zhou Zenggui Wu Linhang Mei Zhaosheng Ma Binbin Cui Feilin Cao |
| author_sort | Xingqiang Yan |
| collection | DOAJ |
| description | Low-grade adenosquamous carcinoma (LGASC) is a rare invasive tumor that occurs in breast parenchyma. It has previously only been reported in females. Herein, we describe the case of a 52-year-old male who presented with a palpable mass in his right axilla that he reported had been present for 20-years. This is the first report of a male patient with LGASC. Core needle biopsy pathology revealed a benign mass of mammary origin, but its type was initially misdiagnosed. It was only correctly identified via postoperative pathology after local excision, which indicated that the mass exhibited the typical pathological characteristics of LGASC. Immunohistochemical analysis revealed positive expression of estrogen receptor, which was inconsistent with the typical “triple-negative” immunophenotype of LGASC. After resection of the mass the patient was advised to participate in regular outpatient follow-up. In conclusion, LGASC should be considered in male patients with a mass lesion in their breast or axilla, even when core needle biopsy indicates a benign mass of breast origin. One-stage local resection is recommended for the treatment of male patients with LGASC, but it is crucial to ensure that the margins are negative and postoperative adjuvant radiotherapy is not recommended. |
| first_indexed | 2024-12-21T00:15:11Z |
| format | Article |
| id | doaj.art-f495e313c7e84c27ad27517cfbb3d3f5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T00:15:11Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f495e313c7e84c27ad27517cfbb3d3f52022-12-21T19:22:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.01714554911Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature ReviewXingqiang Yan0Fanshuang Zhu1Qiupeng Wang2Lijie Chen3Yixing Zhou4Zenggui Wu5Linhang Mei6Zhaosheng Ma7Binbin Cui8Feilin Cao9Department of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Pathology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Wenzhou, ChinaLow-grade adenosquamous carcinoma (LGASC) is a rare invasive tumor that occurs in breast parenchyma. It has previously only been reported in females. Herein, we describe the case of a 52-year-old male who presented with a palpable mass in his right axilla that he reported had been present for 20-years. This is the first report of a male patient with LGASC. Core needle biopsy pathology revealed a benign mass of mammary origin, but its type was initially misdiagnosed. It was only correctly identified via postoperative pathology after local excision, which indicated that the mass exhibited the typical pathological characteristics of LGASC. Immunohistochemical analysis revealed positive expression of estrogen receptor, which was inconsistent with the typical “triple-negative” immunophenotype of LGASC. After resection of the mass the patient was advised to participate in regular outpatient follow-up. In conclusion, LGASC should be considered in male patients with a mass lesion in their breast or axilla, even when core needle biopsy indicates a benign mass of breast origin. One-stage local resection is recommended for the treatment of male patients with LGASC, but it is crucial to ensure that the margins are negative and postoperative adjuvant radiotherapy is not recommended.https://www.frontiersin.org/articles/10.3389/fonc.2020.01714/fullbreastcancerestrogen receptorlow-grade adenosquamous carcinomametaplastic carcinoma |
| spellingShingle | Xingqiang Yan Fanshuang Zhu Qiupeng Wang Lijie Chen Yixing Zhou Zenggui Wu Linhang Mei Zhaosheng Ma Binbin Cui Feilin Cao Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review Frontiers in Oncology breast cancer estrogen receptor low-grade adenosquamous carcinoma metaplastic carcinoma |
| title | Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review |
| title_full | Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review |
| title_fullStr | Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review |
| title_full_unstemmed | Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review |
| title_short | Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review |
| title_sort | low grade adenosquamous carcinoma of the axilla of breast origin in a male a case report and literature review |
| topic | breast cancer estrogen receptor low-grade adenosquamous carcinoma metaplastic carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.01714/full |
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