Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade
Tissue-resident memory T (TRM) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that TRM cells are also enriched within tumo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01655/full |
| _version_ | 1818700191402819584 |
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| author | Kavita M. Dhodapkar |
| author_facet | Kavita M. Dhodapkar |
| author_sort | Kavita M. Dhodapkar |
| collection | DOAJ |
| description | Tissue-resident memory T (TRM) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that TRM cells are also enriched within tumor tissue. Expression of inhibitory immune checkpoints (ICPs) is particularly enriched on this subset of tumor-infiltrating T cells, suggesting that they are major targets for newer therapies targeting ICPs such as the programmed death-1 pathway. Recent studies suggest that tissue restriction of these cells without recirculation may also lead to heterogeneity of TRM cells within individual metastatic lesions, ultimately leading to inter-lesional diversity. Thus, individual metastatic lesions may contain genomically distinct immune microenvironments that impact both evolution of tumors as well as the mechanisms underlying response and resistance to immune therapies. Understanding the biology of TRM cells infiltrating tumors will be essential to improving immune-based approaches in diverse settings. |
| first_indexed | 2024-12-17T15:01:01Z |
| format | Article |
| id | doaj.art-f496be01b22249b090e5f5d021b76092 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T15:01:01Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f496be01b22249b090e5f5d021b760922022-12-21T21:43:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01655387562Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint BlockadeKavita M. DhodapkarTissue-resident memory T (TRM) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that TRM cells are also enriched within tumor tissue. Expression of inhibitory immune checkpoints (ICPs) is particularly enriched on this subset of tumor-infiltrating T cells, suggesting that they are major targets for newer therapies targeting ICPs such as the programmed death-1 pathway. Recent studies suggest that tissue restriction of these cells without recirculation may also lead to heterogeneity of TRM cells within individual metastatic lesions, ultimately leading to inter-lesional diversity. Thus, individual metastatic lesions may contain genomically distinct immune microenvironments that impact both evolution of tumors as well as the mechanisms underlying response and resistance to immune therapies. Understanding the biology of TRM cells infiltrating tumors will be essential to improving immune-based approaches in diverse settings.https://www.frontiersin.org/article/10.3389/fimmu.2018.01655/fulltissue-resident memory cellsimmune checkpoint blockadetumor heterogeneitycancer immunotherapyimmunity to cancer |
| spellingShingle | Kavita M. Dhodapkar Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade Frontiers in Immunology tissue-resident memory cells immune checkpoint blockade tumor heterogeneity cancer immunotherapy immunity to cancer |
| title | Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |
| title_full | Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |
| title_fullStr | Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |
| title_full_unstemmed | Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |
| title_short | Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |
| title_sort | role of tissue resident memory in intra tumor heterogeneity and response to immune checkpoint blockade |
| topic | tissue-resident memory cells immune checkpoint blockade tumor heterogeneity cancer immunotherapy immunity to cancer |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01655/full |
| work_keys_str_mv | AT kavitamdhodapkar roleoftissueresidentmemoryinintratumorheterogeneityandresponsetoimmunecheckpointblockade |