New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers
N6-Methyladenosine (m6A) methylation is one of the most extremely examined RNA modifications. M6A modification evidently impacts cancer development by effecting RNA metabolism. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in multiple essential biological processes by regulating...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1157797/full |
| _version_ | 1827921720241029120 |
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| author | Tao Su Tao Su Jiandong Liu Nasha Zhang Nasha Zhang Teng Wang Linyu Han Suzhen Wang Ming Yang Ming Yang Ming Yang Ming Yang |
| author_facet | Tao Su Tao Su Jiandong Liu Nasha Zhang Nasha Zhang Teng Wang Linyu Han Suzhen Wang Ming Yang Ming Yang Ming Yang Ming Yang |
| author_sort | Tao Su |
| collection | DOAJ |
| description | N6-Methyladenosine (m6A) methylation is one of the most extremely examined RNA modifications. M6A modification evidently impacts cancer development by effecting RNA metabolism. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in multiple essential biological processes by regulating gene expression at the transcriptional and post-transcriptional levels. Accumulated evidences indicated that m6A is involved in regulating the cleavage, stability, structure, transcription, and transport of lncRNAs or miRNAs. Additionally, ncRNAs also play significant roles in modulating m6A levels of malignant cells by participating in the regulation of m6A methyltransferases, the m6A demethylases and the m6A binding proteins. In this review, we systematically summarize the new insight on the interactions between m6A and lncRNAs or miRNAs, as well as their impacts on gastrointestinal cancer progression. Although there are still extensive studies on genome-wide screening of crucial lncRNAs or miRNAs involved in regulating m6A levels of mRNAs and disclosing differences on mechanisms of regulating m6A modification of lncRNAs, miRNAs or mRNAs in cancer cells, we believe that targeting m6A-related lncRNAs and miRNAs may provide novel options for gastrointestinal cancer treatments. |
| first_indexed | 2024-03-13T04:31:30Z |
| format | Article |
| id | doaj.art-f497795aa301403d9e7b47c30e5fa68b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-13T04:31:30Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f497795aa301403d9e7b47c30e5fa68b2023-06-19T13:12:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-06-011110.3389/fcell.2023.11577971157797New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancersTao Su0Tao Su1Jiandong Liu2Nasha Zhang3Nasha Zhang4Teng Wang5Linyu Han6Suzhen Wang7Ming Yang8Ming Yang9Ming Yang10Ming Yang11Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaShandong University Cancer Center, Jinan, Shandong, ChinaShandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaJiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, ChinaShandong University Cancer Center, Jinan, Shandong, ChinaShandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaShandong University Cancer Center, Jinan, Shandong, ChinaShandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Jinan, Shandong, ChinaJiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, ChinaN6-Methyladenosine (m6A) methylation is one of the most extremely examined RNA modifications. M6A modification evidently impacts cancer development by effecting RNA metabolism. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in multiple essential biological processes by regulating gene expression at the transcriptional and post-transcriptional levels. Accumulated evidences indicated that m6A is involved in regulating the cleavage, stability, structure, transcription, and transport of lncRNAs or miRNAs. Additionally, ncRNAs also play significant roles in modulating m6A levels of malignant cells by participating in the regulation of m6A methyltransferases, the m6A demethylases and the m6A binding proteins. In this review, we systematically summarize the new insight on the interactions between m6A and lncRNAs or miRNAs, as well as their impacts on gastrointestinal cancer progression. Although there are still extensive studies on genome-wide screening of crucial lncRNAs or miRNAs involved in regulating m6A levels of mRNAs and disclosing differences on mechanisms of regulating m6A modification of lncRNAs, miRNAs or mRNAs in cancer cells, we believe that targeting m6A-related lncRNAs and miRNAs may provide novel options for gastrointestinal cancer treatments.https://www.frontiersin.org/articles/10.3389/fcell.2023.1157797/fullm6A modificationRNA modificationncRNAmicroRNAlncRNA |
| spellingShingle | Tao Su Tao Su Jiandong Liu Nasha Zhang Nasha Zhang Teng Wang Linyu Han Suzhen Wang Ming Yang Ming Yang Ming Yang Ming Yang New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers Frontiers in Cell and Developmental Biology m6A modification RNA modification ncRNA microRNA lncRNA |
| title | New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers |
| title_full | New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers |
| title_fullStr | New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers |
| title_full_unstemmed | New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers |
| title_short | New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers |
| title_sort | new insights on the interplays between m6a modifications and microrna or lncrna in gastrointestinal cancers |
| topic | m6A modification RNA modification ncRNA microRNA lncRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1157797/full |
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