The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study
Abstract Background Interactions between risk factors may influence disease severity. Knowing this relationship is important for preventive interventions and disease control. The purpose of this study was to determine the interactions effects of obesity and hypertension on the risk of type 2 diabete...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-18290-7 |
| _version_ | 1797258977921204224 |
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| author | Yahya Pasdar Shahab Rezaeian Ehsan Mohammadi Fatemeh Khosravi shadmani Narges Shahnazi Farid Najafi Mehdi Moradi Nazar Mitra Darbandi |
| author_facet | Yahya Pasdar Shahab Rezaeian Ehsan Mohammadi Fatemeh Khosravi shadmani Narges Shahnazi Farid Najafi Mehdi Moradi Nazar Mitra Darbandi |
| author_sort | Yahya Pasdar |
| collection | DOAJ |
| description | Abstract Background Interactions between risk factors may influence disease severity. Knowing this relationship is important for preventive interventions and disease control. The purpose of this study was to determine the interactions effects of obesity and hypertension on the risk of type 2 diabetes mellitus (T2DM). Methods The data of 9,283 adults 35 to 65 years were examined from the cohort study of Ravansar Non-Communicable Disease (RaNCD). Waist circumference (WC) was used to identify both general and abdominal obesity based on body mass index (BMI). To assess the interaction between hypertension and obesity (general/abdominal) and the risk of T2DM, the additive interaction was calculated. Results The adjusted odds ratios for T2DM were 2.38 (1.67, 3.41) in men and 4.02 (2.47, 6.47) in women for the combinations of hypertension and abdominal obesity. The adjusted odds ratios for T2DM were 2.53 (1.63, 3.82) in men and 2.66 (1.92, 3.70) in women for the combinations of hypertension and general obesity. The results of the additive interaction indicators were inconsistent with gender. The relative excess risk due to interaction (interaction between hypertension and central obesity) (RERI), attributable proportion due to interaction (AP) and synergy index (SI) were0.27 (-1.01, 1.54), 0.11 (-0.41, 0.63) and 1.23 (0.41, 3.68) in male and were 0.61 (-1.12, 2.33), 0.23 (0.08, 0.37) and 1.26 (0.60, 2.61) in female, respectively. Conclusion General/abdominal obesity and hypertension have a synergistic effect on the risk of T2DM. The recommendation for preventing T2DM is lifestyle modification. Large longitudinal studies are necessary to investigate causal relationships. |
| first_indexed | 2024-04-24T23:02:07Z |
| format | Article |
| id | doaj.art-f49a15fe9e694529bf88d73ca17972db |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-24T23:02:07Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-f49a15fe9e694529bf88d73ca17972db2024-03-17T12:41:14ZengBMCBMC Public Health1471-24582024-03-012411810.1186/s12889-024-18290-7The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort studyYahya Pasdar0Shahab Rezaeian1Ehsan Mohammadi2Fatemeh Khosravi shadmani3Narges Shahnazi4Farid Najafi5Mehdi Moradi Nazar6Mitra Darbandi7Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesInfectious Disease Research Center, Health Institute, Kermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesKermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesAbstract Background Interactions between risk factors may influence disease severity. Knowing this relationship is important for preventive interventions and disease control. The purpose of this study was to determine the interactions effects of obesity and hypertension on the risk of type 2 diabetes mellitus (T2DM). Methods The data of 9,283 adults 35 to 65 years were examined from the cohort study of Ravansar Non-Communicable Disease (RaNCD). Waist circumference (WC) was used to identify both general and abdominal obesity based on body mass index (BMI). To assess the interaction between hypertension and obesity (general/abdominal) and the risk of T2DM, the additive interaction was calculated. Results The adjusted odds ratios for T2DM were 2.38 (1.67, 3.41) in men and 4.02 (2.47, 6.47) in women for the combinations of hypertension and abdominal obesity. The adjusted odds ratios for T2DM were 2.53 (1.63, 3.82) in men and 2.66 (1.92, 3.70) in women for the combinations of hypertension and general obesity. The results of the additive interaction indicators were inconsistent with gender. The relative excess risk due to interaction (interaction between hypertension and central obesity) (RERI), attributable proportion due to interaction (AP) and synergy index (SI) were0.27 (-1.01, 1.54), 0.11 (-0.41, 0.63) and 1.23 (0.41, 3.68) in male and were 0.61 (-1.12, 2.33), 0.23 (0.08, 0.37) and 1.26 (0.60, 2.61) in female, respectively. Conclusion General/abdominal obesity and hypertension have a synergistic effect on the risk of T2DM. The recommendation for preventing T2DM is lifestyle modification. Large longitudinal studies are necessary to investigate causal relationships.https://doi.org/10.1186/s12889-024-18290-7Abdominal obesityGeneral obesityHypertensionDiabetes mellitus |
| spellingShingle | Yahya Pasdar Shahab Rezaeian Ehsan Mohammadi Fatemeh Khosravi shadmani Narges Shahnazi Farid Najafi Mehdi Moradi Nazar Mitra Darbandi The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study BMC Public Health Abdominal obesity General obesity Hypertension Diabetes mellitus |
| title | The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study |
| title_full | The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study |
| title_fullStr | The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study |
| title_full_unstemmed | The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study |
| title_short | The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study |
| title_sort | interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus a cross sectional analysis in iranian adults from the rancd cohort study |
| topic | Abdominal obesity General obesity Hypertension Diabetes mellitus |
| url | https://doi.org/10.1186/s12889-024-18290-7 |
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