Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration
Abstract We investigated the incidence and risk factors of late age-related macular degeneration (AMD) in the fellow eye (FE) without significant drusen of patients with unilateral exudative macular neovascularization (MNV). In this retrospective study, 241 eligible patients who were followed-up for...
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-04798-8 |
| _version_ | 1819008442660028416 |
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| author | Junwon Lee Hyun Goo Kang Hae Rang Kim Christopher Seungkyu Lee Min Kim Sung Soo Kim Suk Ho Byeon |
| author_facet | Junwon Lee Hyun Goo Kang Hae Rang Kim Christopher Seungkyu Lee Min Kim Sung Soo Kim Suk Ho Byeon |
| author_sort | Junwon Lee |
| collection | DOAJ |
| description | Abstract We investigated the incidence and risk factors of late age-related macular degeneration (AMD) in the fellow eye (FE) without significant drusen of patients with unilateral exudative macular neovascularization (MNV). In this retrospective study, 241 eligible patients who were followed-up for more than 3 years were enrolled. We analyzed the incidence and hazard ratios (HRs) of late AMD in the FE according to demographic and ophthalmologic variables. Hypopigmentation on color fundus photography (CFP) corresponds to shallow irregular RPE elevation (SIRE), so-called “double-layer sign” and/or “attenuation or disruption of RPE and/or ellipsoid zone” on OCT. The 5-year incidence of FE exudative MNV conversion was 8.6%. The 5-year incidence of FE exudative MNV of large hypopigmentation (≥ 0.5 disc area; DA) and small hypopigmentation (< 0.5 DA) on CFP, and SIRE (≥ 1000 µm) and small RPE elevation (< 1000 µm) on OCT were 36.2%, 14.2%, 55.0%, and 15.6%, respectively. The multivariate Cox proportional hazard model revealed that large hypopigmentation, small hypopigmentation, SIRE, and small RPE elevation showed HRs of 23.230, 8.037, 132.589, and 41.823 for FE exudative MNV occurrence, respectively. Hypopigmentation on CFP and SIRE on OCT could represent the same lesion. Even small hypopigmentation and small RPE elevation were significant risk factors for progression to exudative MNV. |
| first_indexed | 2024-12-21T00:40:33Z |
| format | Article |
| id | doaj.art-f49a484700ea46d2a2b9c6e8804314d3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T00:40:33Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f49a484700ea46d2a2b9c6e8804314d32022-12-21T19:21:41ZengNature PortfolioScientific Reports2045-23222022-01-011211910.1038/s41598-022-04798-8Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degenerationJunwon Lee0Hyun Goo Kang1Hae Rang Kim2Christopher Seungkyu Lee3Min Kim4Sung Soo Kim5Suk Ho Byeon6Department of Ophthalmology, Institute of Human Barrier Research, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Human Barrier Research, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Eye Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Eye Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Human Barrier Research, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Eye Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Eye Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineAbstract We investigated the incidence and risk factors of late age-related macular degeneration (AMD) in the fellow eye (FE) without significant drusen of patients with unilateral exudative macular neovascularization (MNV). In this retrospective study, 241 eligible patients who were followed-up for more than 3 years were enrolled. We analyzed the incidence and hazard ratios (HRs) of late AMD in the FE according to demographic and ophthalmologic variables. Hypopigmentation on color fundus photography (CFP) corresponds to shallow irregular RPE elevation (SIRE), so-called “double-layer sign” and/or “attenuation or disruption of RPE and/or ellipsoid zone” on OCT. The 5-year incidence of FE exudative MNV conversion was 8.6%. The 5-year incidence of FE exudative MNV of large hypopigmentation (≥ 0.5 disc area; DA) and small hypopigmentation (< 0.5 DA) on CFP, and SIRE (≥ 1000 µm) and small RPE elevation (< 1000 µm) on OCT were 36.2%, 14.2%, 55.0%, and 15.6%, respectively. The multivariate Cox proportional hazard model revealed that large hypopigmentation, small hypopigmentation, SIRE, and small RPE elevation showed HRs of 23.230, 8.037, 132.589, and 41.823 for FE exudative MNV occurrence, respectively. Hypopigmentation on CFP and SIRE on OCT could represent the same lesion. Even small hypopigmentation and small RPE elevation were significant risk factors for progression to exudative MNV.https://doi.org/10.1038/s41598-022-04798-8 |
| spellingShingle | Junwon Lee Hyun Goo Kang Hae Rang Kim Christopher Seungkyu Lee Min Kim Sung Soo Kim Suk Ho Byeon Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration Scientific Reports |
| title | Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration |
| title_full | Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration |
| title_fullStr | Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration |
| title_full_unstemmed | Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration |
| title_short | Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration |
| title_sort | pigmentary abnormality without significant drusen as a risk factor for late age related macular degeneration |
| url | https://doi.org/10.1038/s41598-022-04798-8 |
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