Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials
Abstract Background The current studies explore the effect of omega-3 polyunsaturated fatty acids (PUFAs) on appetite. Objective To examine the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on appetite using a systematic review and meta-analysis of controlled clinical trials (CTs). Patie...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-023-02430-y |
| _version_ | 1797276715169349632 |
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| author | Bahareh Sasanfar Fatemeh Toorang Amin Salehi-Abarghouei |
| author_facet | Bahareh Sasanfar Fatemeh Toorang Amin Salehi-Abarghouei |
| author_sort | Bahareh Sasanfar |
| collection | DOAJ |
| description | Abstract Background The current studies explore the effect of omega-3 polyunsaturated fatty acids (PUFAs) on appetite. Objective To examine the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on appetite using a systematic review and meta-analysis of controlled clinical trials (CTs). Patients and methods Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to January 2022. A random-effects model was used to compare the overall standardized mean difference in appetite scores between n-3 PUFAs supplemented and control individuals. Results Fifteen eligible CTs with 1504 participants (872 for n-3 PUFA supplementation and 632 for placebo groups) were included in our systematic review. The meta-analysis showed no significant difference in overall appetite score between n-3 PUFAs supplemented and control groups (standardized mean difference [SMD] = 0.458, 95% confidence interval [CI] − 0.327, 1.242, P value = 0.25). However, the n-3 PUFA supplementation significantly increased the desire to eat (SMD = 1.07, 95% CI 0.116, 2.029, P = 0.02) compared to control. Conclusion Although we found no effect of omega-3 supplementation on overall appetite score, it modestly increases the desire to eat. Further CTs evaluating the effect of PUFAs on appetite are still needed to confirm these findings. |
| first_indexed | 2024-03-07T15:33:13Z |
| format | Article |
| id | doaj.art-f49bbf2b2606487185e1d7c965620791 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-03-07T15:33:13Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-f49bbf2b2606487185e1d7c9656207912024-03-05T16:21:30ZengBMCSystematic Reviews2046-40532024-01-0113111110.1186/s13643-023-02430-yEffects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trialsBahareh Sasanfar0Fatemeh Toorang1Amin Salehi-Abarghouei2Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical SciencesCancer Research Center, Cancer Institute of Iran, Tehran University of Medical SciencesResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical SciencesAbstract Background The current studies explore the effect of omega-3 polyunsaturated fatty acids (PUFAs) on appetite. Objective To examine the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on appetite using a systematic review and meta-analysis of controlled clinical trials (CTs). Patients and methods Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to January 2022. A random-effects model was used to compare the overall standardized mean difference in appetite scores between n-3 PUFAs supplemented and control individuals. Results Fifteen eligible CTs with 1504 participants (872 for n-3 PUFA supplementation and 632 for placebo groups) were included in our systematic review. The meta-analysis showed no significant difference in overall appetite score between n-3 PUFAs supplemented and control groups (standardized mean difference [SMD] = 0.458, 95% confidence interval [CI] − 0.327, 1.242, P value = 0.25). However, the n-3 PUFA supplementation significantly increased the desire to eat (SMD = 1.07, 95% CI 0.116, 2.029, P = 0.02) compared to control. Conclusion Although we found no effect of omega-3 supplementation on overall appetite score, it modestly increases the desire to eat. Further CTs evaluating the effect of PUFAs on appetite are still needed to confirm these findings.https://doi.org/10.1186/s13643-023-02430-yn-3 polyunsaturated fatty acidsAppetiteVisual analog scaleSystematic reviewMeta-analysis |
| spellingShingle | Bahareh Sasanfar Fatemeh Toorang Amin Salehi-Abarghouei Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials Systematic Reviews n-3 polyunsaturated fatty acids Appetite Visual analog scale Systematic review Meta-analysis |
| title | Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials |
| title_full | Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials |
| title_fullStr | Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials |
| title_full_unstemmed | Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials |
| title_short | Effects of n-3 polyunsaturated fatty acid supplementation on appetite: a systematic review and meta-analysis of controlled clinical trials |
| title_sort | effects of n 3 polyunsaturated fatty acid supplementation on appetite a systematic review and meta analysis of controlled clinical trials |
| topic | n-3 polyunsaturated fatty acids Appetite Visual analog scale Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s13643-023-02430-y |
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