PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated recep...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1169019/full |
| _version_ | 1797851406095351808 |
|---|---|
| author | Haochen Wang Jianbang Su Minghao Yu Yang Xia Yingliang Wei |
| author_facet | Haochen Wang Jianbang Su Minghao Yu Yang Xia Yingliang Wei |
| author_sort | Haochen Wang |
| collection | DOAJ |
| description | Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA by affecting mitochondrial biogenesis, oxidative stress, mitophagy and mitochondrial DNA (mtDNA) replication in chondrocytes. In addition, PGC-1α can regulate the metabolic abnormalities of OA chondrocytes and inhibit chondrocyte apoptosis. In this paper, we review the regulatory mechanisms of PGC-1α and its effects on OA chondrocytes, and introduce potential drugs and novel nanohybrid for the treatment of OA which act by affecting the activity of PGC-1α. This information will help to further elucidate the pathogenesis of OA and provide new ideas for the development of therapeutic strategies for OA. |
| first_indexed | 2024-04-09T19:17:24Z |
| format | Article |
| id | doaj.art-f49bc504a429417988afb4a035b24bf0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:17:24Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f49bc504a429417988afb4a035b24bf02023-04-06T05:22:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11690191169019PGC-1α in osteoarthritic chondrocytes: From mechanism to target of actionHaochen Wang0Jianbang Su1Minghao Yu2Yang Xia3Yingliang Wei4Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaOsteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA by affecting mitochondrial biogenesis, oxidative stress, mitophagy and mitochondrial DNA (mtDNA) replication in chondrocytes. In addition, PGC-1α can regulate the metabolic abnormalities of OA chondrocytes and inhibit chondrocyte apoptosis. In this paper, we review the regulatory mechanisms of PGC-1α and its effects on OA chondrocytes, and introduce potential drugs and novel nanohybrid for the treatment of OA which act by affecting the activity of PGC-1α. This information will help to further elucidate the pathogenesis of OA and provide new ideas for the development of therapeutic strategies for OA.https://www.frontiersin.org/articles/10.3389/fphar.2023.1169019/fullosteoarthritischondrocytePGC- 1αmetabolismapoptosismitochondria |
| spellingShingle | Haochen Wang Jianbang Su Minghao Yu Yang Xia Yingliang Wei PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action Frontiers in Pharmacology osteoarthritis chondrocyte PGC- 1α metabolism apoptosis mitochondria |
| title | PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action |
| title_full | PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action |
| title_fullStr | PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action |
| title_full_unstemmed | PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action |
| title_short | PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action |
| title_sort | pgc 1α in osteoarthritic chondrocytes from mechanism to target of action |
| topic | osteoarthritis chondrocyte PGC- 1α metabolism apoptosis mitochondria |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1169019/full |
| work_keys_str_mv | AT haochenwang pgc1ainosteoarthriticchondrocytesfrommechanismtotargetofaction AT jianbangsu pgc1ainosteoarthriticchondrocytesfrommechanismtotargetofaction AT minghaoyu pgc1ainosteoarthriticchondrocytesfrommechanismtotargetofaction AT yangxia pgc1ainosteoarthriticchondrocytesfrommechanismtotargetofaction AT yingliangwei pgc1ainosteoarthriticchondrocytesfrommechanismtotargetofaction |