Emodin Ameliorates Acute Pancreatitis-Associated Lung Injury Through Inhibiting the Alveolar Macrophages Pyroptosis

Emodin Ameliorates Acute Pancreatitis-Associated Lung Injury Through Inhibiting the Alveolar Macrophages Pyroptosis

Objective: To investigate the protective effect of emodin in acute pancreatitis (AP)-associated lung injury and the underlying mechanisms.Methods: NaT-AP model in rats was constructed using 3.5% sodium taurocholate, and CER+LPS-AP model in mice was constructed using caerulein combined with Lipopolys...

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Bibliographic Details
Main Authors: Xiajia Wu, Jiaqi Yao, Qian Hu, Hongxin Kang, Yifan Miao, Lv Zhu, Cong Li, Xianlin Zhao, Juan Li, Meihua Wan, Wenfu Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
emodin
NLRP3 inflammasome
alveolar macrophage
pyroptosis
acute pancreatitis
acute lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.873053/full

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