DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model

DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model

SARS-CoV-2 infections present a tremendous threat to public health. Safe and efficacious vaccines are the most effective means in preventing the infections. A variety of vaccines have demonstrated excellent efficacy and safety around the globe. Yet, development of alternative forms of vaccines remai...

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Bibliographic Details
Main Authors: Levi A. Tamming, Diana Duque, Anh Tran, Wanyue Zhang, Annabelle Pfeifle, Emmanuel Laryea, Jianguo Wu, Sathya N. Thulasi Raman, Caroline Gravel, Marsha S. Russell, Anwar M. Hashem, Reem M. Alsulaiman, Rowa Y. Alhabbab, Jun Gao, David Safronetz, Jingxin Cao, Lisheng Wang, Wangxue Chen, Michael J. W. Johnston, Simon Sauve, Michael Rosu-Myles, Xuguang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
coronavirus
vaccination
DNA
antibody response
pathology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.785349/full

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