High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures
To determine whether stress fractures are associated with bone microstructural deterioration we quantified distal radial and the unfractured distal tibia using high resolution peripheral quantitative computed tomography in 26 cases with lower limb stress fractures (15 males, 11 females; mean age 37....
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/1123 |
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| author | Afrodite Zendeli Minh Bui Lukas Fischer Ali Ghasem-Zadeh Wolfgang Schima Ego Seeman |
| author_facet | Afrodite Zendeli Minh Bui Lukas Fischer Ali Ghasem-Zadeh Wolfgang Schima Ego Seeman |
| author_sort | Afrodite Zendeli |
| collection | DOAJ |
| description | To determine whether stress fractures are associated with bone microstructural deterioration we quantified distal radial and the unfractured distal tibia using high resolution peripheral quantitative computed tomography in 26 cases with lower limb stress fractures (15 males, 11 females; mean age 37.1 ± 3.1 years) and 62 age-matched healthy controls (24 males, 38 females; mean age 35.0 ± 1.6 years). Relative to controls, in men, at the distal radius, cases had smaller cortical cross sectional area (CSA) (<i>p</i> = 0.012), higher porosity of the outer transitional zone (OTZ) (<i>p</i> = 0.006), inner transitional zone (ITZ) (<i>p</i> = 0.043) and the compact-appearing cortex (CC) (<i>p</i> = 0.023) while trabecular vBMD was lower (<i>p</i> = 0.002). At the distal tibia, cases also had a smaller cortical CSA (<i>p</i> = 0.008). Cortical porosity was not higher, but trabecular vBMD was lower (<i>p</i> = 0.001). Relative to controls, in women, cases had higher distal radial porosity of the OTZ (<i>p</i> = 0.028), ITZ (<i>p</i> = 0.030) not CC (<i>p</i> = 0.054). Trabecular vBMD was lower (<i>p</i> = 0.041). Distal tibial porosity was higher in the OTZ (<i>p</i> = 0.035), ITZ (<i>p</i> = 0.009), not CC. Stress fractures are associated with compromised cortical and trabecular microstructure. |
| first_indexed | 2024-03-09T05:01:37Z |
| format | Article |
| id | doaj.art-f4a06f6de6424e26946062d60591eab4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:01:37Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f4a06f6de6424e26946062d60591eab42023-12-03T13:00:15ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01105112310.3390/jcm10051123High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress FracturesAfrodite Zendeli0Minh Bui1Lukas Fischer2Ali Ghasem-Zadeh3Wolfgang Schima4Ego Seeman5Medical Department of Internal Medicine, Rheumatology and Endocrinology at Krankenhaus Herz Jesu, 1030 Vienna, AustriaCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne 3000, AustraliaComputational Imaging Research Lab, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, AustriaDepartments Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne 3084, AustraliaDepartment of Diagnostic and Interventional Radiology–Barmherzige Schwestern Krankenhaus, Goettlicher Heiland Krankenhaus und Sankt Josef Krankenhaus, 1060 Vienna, AustriaDepartments Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne 3084, AustraliaTo determine whether stress fractures are associated with bone microstructural deterioration we quantified distal radial and the unfractured distal tibia using high resolution peripheral quantitative computed tomography in 26 cases with lower limb stress fractures (15 males, 11 females; mean age 37.1 ± 3.1 years) and 62 age-matched healthy controls (24 males, 38 females; mean age 35.0 ± 1.6 years). Relative to controls, in men, at the distal radius, cases had smaller cortical cross sectional area (CSA) (<i>p</i> = 0.012), higher porosity of the outer transitional zone (OTZ) (<i>p</i> = 0.006), inner transitional zone (ITZ) (<i>p</i> = 0.043) and the compact-appearing cortex (CC) (<i>p</i> = 0.023) while trabecular vBMD was lower (<i>p</i> = 0.002). At the distal tibia, cases also had a smaller cortical CSA (<i>p</i> = 0.008). Cortical porosity was not higher, but trabecular vBMD was lower (<i>p</i> = 0.001). Relative to controls, in women, cases had higher distal radial porosity of the OTZ (<i>p</i> = 0.028), ITZ (<i>p</i> = 0.030) not CC (<i>p</i> = 0.054). Trabecular vBMD was lower (<i>p</i> = 0.041). Distal tibial porosity was higher in the OTZ (<i>p</i> = 0.035), ITZ (<i>p</i> = 0.009), not CC. Stress fractures are associated with compromised cortical and trabecular microstructure.https://www.mdpi.com/2077-0383/10/5/1123bone microstructural deteriorationcortical porosityhigh resolution peripheral quantitative computed tomographystress fracture |
| spellingShingle | Afrodite Zendeli Minh Bui Lukas Fischer Ali Ghasem-Zadeh Wolfgang Schima Ego Seeman High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures Journal of Clinical Medicine bone microstructural deterioration cortical porosity high resolution peripheral quantitative computed tomography stress fracture |
| title | High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures |
| title_full | High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures |
| title_fullStr | High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures |
| title_full_unstemmed | High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures |
| title_short | High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures |
| title_sort | high cortico trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures |
| topic | bone microstructural deterioration cortical porosity high resolution peripheral quantitative computed tomography stress fracture |
| url | https://www.mdpi.com/2077-0383/10/5/1123 |
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