Prostaglandin E2 receptors as therapeutic targets in renal fibrosis
Prostaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water and salt balance, and renal fibrosis—a key pa...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-01-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-222.pdf |
| _version_ | 1811311947935645696 |
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| author | Henricus A.M. Mutsaers Rikke Nørregaard |
| author_facet | Henricus A.M. Mutsaers Rikke Nørregaard |
| author_sort | Henricus A.M. Mutsaers |
| collection | DOAJ |
| description | Prostaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water and salt balance, and renal fibrosis—a key pathological feature of progressive kidney diseases. PGE2 functions by binding to four G-protein-coupled EP receptors (EP1 to EP4), which stimulate different intracellular signaling pathways. The intrarenal distribution of the four EP receptors as well as the different downstream signaling pathways associated with each receptor give rise to the distinct functional consequence of activating each receptor subtype. This review summarizes the current data on the renal expression of the four EP receptors and delineates the role of each receptor in renal fibrosis. |
| first_indexed | 2024-04-13T10:27:54Z |
| format | Article |
| id | doaj.art-f4a0758dd3974a2fb4653f21e13c32f1 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-13T10:27:54Z |
| publishDate | 2022-01-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-f4a0758dd3974a2fb4653f21e13c32f12022-12-22T02:50:16ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-01-0141141310.23876/j.krcp.21.2226100Prostaglandin E2 receptors as therapeutic targets in renal fibrosisHenricus A.M. Mutsaers0Rikke Nørregaard1 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkProstaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water and salt balance, and renal fibrosis—a key pathological feature of progressive kidney diseases. PGE2 functions by binding to four G-protein-coupled EP receptors (EP1 to EP4), which stimulate different intracellular signaling pathways. The intrarenal distribution of the four EP receptors as well as the different downstream signaling pathways associated with each receptor give rise to the distinct functional consequence of activating each receptor subtype. This review summarizes the current data on the renal expression of the four EP receptors and delineates the role of each receptor in renal fibrosis.http://www.krcp-ksn.org/upload/pdf/j-krcp-21-222.pdfchronic kidney diseasecyclooxygenase-2prostaglandin e2renal fibrosis |
| spellingShingle | Henricus A.M. Mutsaers Rikke Nørregaard Prostaglandin E2 receptors as therapeutic targets in renal fibrosis Kidney Research and Clinical Practice chronic kidney disease cyclooxygenase-2 prostaglandin e2 renal fibrosis |
| title | Prostaglandin E2 receptors as therapeutic targets in renal fibrosis |
| title_full | Prostaglandin E2 receptors as therapeutic targets in renal fibrosis |
| title_fullStr | Prostaglandin E2 receptors as therapeutic targets in renal fibrosis |
| title_full_unstemmed | Prostaglandin E2 receptors as therapeutic targets in renal fibrosis |
| title_short | Prostaglandin E2 receptors as therapeutic targets in renal fibrosis |
| title_sort | prostaglandin e2 receptors as therapeutic targets in renal fibrosis |
| topic | chronic kidney disease cyclooxygenase-2 prostaglandin e2 renal fibrosis |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-222.pdf |
| work_keys_str_mv | AT henricusammutsaers prostaglandine2receptorsastherapeutictargetsinrenalfibrosis AT rikkenørregaard prostaglandine2receptorsastherapeutictargetsinrenalfibrosis |