In vivo Emergence of Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Premature Termination of the mgrB Gene Regulator

In vivo Emergence of Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Premature Termination of the mgrB Gene Regulator

Multidrug-resistant (MDR) Klebsiella pneumoniae is a severe threat to public health worldwide. Worryingly, colistin resistance, one of the last-line antibiotics for the treatment of MDR K. pneumoniae infection, has been increasingly reported. This study aims to investigate the emergence of evolved c...

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Bibliographic Details
Main Authors: Yingying Kong, Chao Li, Hangfei Chen, Wei Zheng, Qingyang Sun, Xinyou Xie, Jun Zhang, Zhi Ruan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
colistin resistance
mgrB
complementation
whole genome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.656610/full

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