How Diffusion Impacts Cortical Protein Distribution in Yeasts
Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achiev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/5/1113 |
| _version_ | 1827717764030136320 |
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| author | Kyle D. Moran Daniel J. Lew |
| author_facet | Kyle D. Moran Daniel J. Lew |
| author_sort | Kyle D. Moran |
| collection | DOAJ |
| description | Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved. |
| first_indexed | 2024-03-10T20:09:01Z |
| format | Article |
| id | doaj.art-f4a229168417408dabc67218efe6320d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:09:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f4a229168417408dabc67218efe6320d2023-11-19T23:07:28ZengMDPI AGCells2073-44092020-04-0195111310.3390/cells9051113How Diffusion Impacts Cortical Protein Distribution in YeastsKyle D. Moran0Daniel J. Lew1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USADepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USAProteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.https://www.mdpi.com/2073-4409/9/5/1113diffusioncell polarityCdc42 |
| spellingShingle | Kyle D. Moran Daniel J. Lew How Diffusion Impacts Cortical Protein Distribution in Yeasts Cells diffusion cell polarity Cdc42 |
| title | How Diffusion Impacts Cortical Protein Distribution in Yeasts |
| title_full | How Diffusion Impacts Cortical Protein Distribution in Yeasts |
| title_fullStr | How Diffusion Impacts Cortical Protein Distribution in Yeasts |
| title_full_unstemmed | How Diffusion Impacts Cortical Protein Distribution in Yeasts |
| title_short | How Diffusion Impacts Cortical Protein Distribution in Yeasts |
| title_sort | how diffusion impacts cortical protein distribution in yeasts |
| topic | diffusion cell polarity Cdc42 |
| url | https://www.mdpi.com/2073-4409/9/5/1113 |
| work_keys_str_mv | AT kyledmoran howdiffusionimpactscorticalproteindistributioninyeasts AT danieljlew howdiffusionimpactscorticalproteindistributioninyeasts |