Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome
IntroductionAs the repercussions from the COVID-19 pandemic continue to unfold, an ever-expanding body of evidence suggests that infection also elicits pathophysiological manifestations within the central nervous system (CNS), known as neurological symptoms of post-acute sequelae of COVID infection...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1221266/full |
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| author | Jacob Saucier Jacob Saucier Dominique Comeau Gilles A. Robichaud Gilles A. Robichaud Gilles A. Robichaud Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski |
| author_facet | Jacob Saucier Jacob Saucier Dominique Comeau Gilles A. Robichaud Gilles A. Robichaud Gilles A. Robichaud Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski |
| author_sort | Jacob Saucier |
| collection | DOAJ |
| description | IntroductionAs the repercussions from the COVID-19 pandemic continue to unfold, an ever-expanding body of evidence suggests that infection also elicits pathophysiological manifestations within the central nervous system (CNS), known as neurological symptoms of post-acute sequelae of COVID infection (NeuroPASC). Although the neurological impairments and repercussions associated with NeuroPASC have been well described in the literature, its etiology remains to be fully characterized.ObjectivesThis mini-review explores the current literature that elucidates various mechanisms underlining NeuroPASC, its players, and regulators, leading to persistent neuroinflammation of affected individuals. Specifically, we provide some insights into the various roles played by microglial and astroglial cell reactivity in NeuroPASC and how these cell subsets potentially contribute to neurological impairment in response to the direct or indirect mechanisms of CNS injury.DiscussionA better understanding of the mechanisms and biomarkers associated with this maladaptive neuroimmune response will thus provide better diagnostic strategies for NeuroPASC and reveal new potential mechanisms for therapeutic intervention. Altogether, the elucidation of NeuroPASC pathogenesis will improve patient outcomes and mitigate the socioeconomic burden of this syndrome. |
| first_indexed | 2024-03-12T13:26:01Z |
| format | Article |
| id | doaj.art-f4a2de9206f74481b49cdacb4bcd4a74 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T13:26:01Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f4a2de9206f74481b49cdacb4bcd4a742023-08-25T07:17:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.12212661221266Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndromeJacob Saucier0Jacob Saucier1Dominique Comeau2Gilles A. Robichaud3Gilles A. Robichaud4Gilles A. Robichaud5Ludivine Chamard-Witkowski6Ludivine Chamard-Witkowski7Ludivine Chamard-Witkowski8Ludivine Chamard-Witkowski9Centre de Formation Médicale du Nouveau-Brunswick, Moncton, NB, CanadaFaculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, CanadaCentre de médecine de précision du Nouveau-Brunswick, Vitality Health Network, Moncton, NB, CanadaCentre de médecine de précision du Nouveau-Brunswick, Vitality Health Network, Moncton, NB, CanadaDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, CanadaAtlantic Cancer Research Institute, Moncton, NB, CanadaCentre de Formation Médicale du Nouveau-Brunswick, Moncton, NB, CanadaFaculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, CanadaCentre de médecine de précision du Nouveau-Brunswick, Vitality Health Network, Moncton, NB, CanadaDepartment of Neurology, Dr. Georges-L.-Dumont University Hospital Centre, Vitality Health Network, Moncton, NB, CanadaIntroductionAs the repercussions from the COVID-19 pandemic continue to unfold, an ever-expanding body of evidence suggests that infection also elicits pathophysiological manifestations within the central nervous system (CNS), known as neurological symptoms of post-acute sequelae of COVID infection (NeuroPASC). Although the neurological impairments and repercussions associated with NeuroPASC have been well described in the literature, its etiology remains to be fully characterized.ObjectivesThis mini-review explores the current literature that elucidates various mechanisms underlining NeuroPASC, its players, and regulators, leading to persistent neuroinflammation of affected individuals. Specifically, we provide some insights into the various roles played by microglial and astroglial cell reactivity in NeuroPASC and how these cell subsets potentially contribute to neurological impairment in response to the direct or indirect mechanisms of CNS injury.DiscussionA better understanding of the mechanisms and biomarkers associated with this maladaptive neuroimmune response will thus provide better diagnostic strategies for NeuroPASC and reveal new potential mechanisms for therapeutic intervention. Altogether, the elucidation of NeuroPASC pathogenesis will improve patient outcomes and mitigate the socioeconomic burden of this syndrome.https://www.frontiersin.org/articles/10.3389/fneur.2023.1221266/fullpost-COVID syndromeNeuroPASCreactive gliosisneuroinflammationmicroglial reactivityreactive astrocytes |
| spellingShingle | Jacob Saucier Jacob Saucier Dominique Comeau Gilles A. Robichaud Gilles A. Robichaud Gilles A. Robichaud Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Ludivine Chamard-Witkowski Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome Frontiers in Neurology post-COVID syndrome NeuroPASC reactive gliosis neuroinflammation microglial reactivity reactive astrocytes |
| title | Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome |
| title_full | Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome |
| title_fullStr | Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome |
| title_full_unstemmed | Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome |
| title_short | Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome |
| title_sort | reactive gliosis and neuroinflammation prime suspects in the pathophysiology of post acute neurocovid 19 syndrome |
| topic | post-COVID syndrome NeuroPASC reactive gliosis neuroinflammation microglial reactivity reactive astrocytes |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1221266/full |
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