Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer
Galectins have been shown to have roles in cancer progression via their contributions to angiogenesis, metastasis, cell division, and the evasion of immune destruction. This study analyzes galectin-1, -3, and -9 serum concentrations in breast cancer patients through enzyme-linked immunosorbent assay...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/15/3809 |
| _version_ | 1797587057143447552 |
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| author | Avery Funkhouser Hayden Shuster Julie C. Martin W. Jeffery Edenfield Anna V. Blenda |
| author_facet | Avery Funkhouser Hayden Shuster Julie C. Martin W. Jeffery Edenfield Anna V. Blenda |
| author_sort | Avery Funkhouser |
| collection | DOAJ |
| description | Galectins have been shown to have roles in cancer progression via their contributions to angiogenesis, metastasis, cell division, and the evasion of immune destruction. This study analyzes galectin-1, -3, and -9 serum concentrations in breast cancer patients through enzyme-linked immunosorbent assay (ELISA) against the characteristics of the patient and the tumor such as stage, molecular subtype, and receptor expression. Galectin-9 was found to be statistically significantly increased in HER2-enriched tumors and reduced in patients with hormone-receptor-positive tumors. Galectin-1 was found to be statistically significantly increased in the serum of patients who had undergone hormonal, immunotherapy, or chemotherapy. These findings provide insight into the changes in galectin levels during the progress of cancer, the response to treatment, and the molecular phenotype. These findings are valuable in the further understanding of the relationships between galectin and tumor biology and can inform future research on therapeutic targets for galectin inhibitors and the utility of galectin biomarkers. |
| first_indexed | 2024-03-11T00:30:54Z |
| format | Article |
| id | doaj.art-f4a470beda1e4406a2f090c3a10bd262 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:54Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f4a470beda1e4406a2f090c3a10bd2622023-11-18T22:41:43ZengMDPI AGCancers2072-66942023-07-011515380910.3390/cancers15153809Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast CancerAvery Funkhouser0Hayden Shuster1Julie C. Martin2W. Jeffery Edenfield3Anna V. Blenda4Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USADepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USAPrisma Health Cancer Institute, Prisma Health, Greenville, SC 29605, USADepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USADepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USAGalectins have been shown to have roles in cancer progression via their contributions to angiogenesis, metastasis, cell division, and the evasion of immune destruction. This study analyzes galectin-1, -3, and -9 serum concentrations in breast cancer patients through enzyme-linked immunosorbent assay (ELISA) against the characteristics of the patient and the tumor such as stage, molecular subtype, and receptor expression. Galectin-9 was found to be statistically significantly increased in HER2-enriched tumors and reduced in patients with hormone-receptor-positive tumors. Galectin-1 was found to be statistically significantly increased in the serum of patients who had undergone hormonal, immunotherapy, or chemotherapy. These findings provide insight into the changes in galectin levels during the progress of cancer, the response to treatment, and the molecular phenotype. These findings are valuable in the further understanding of the relationships between galectin and tumor biology and can inform future research on therapeutic targets for galectin inhibitors and the utility of galectin biomarkers.https://www.mdpi.com/2072-6694/15/15/3809galectinserumbreast neoplasmmolecular subtypegalectin-1galectin-3 |
| spellingShingle | Avery Funkhouser Hayden Shuster Julie C. Martin W. Jeffery Edenfield Anna V. Blenda Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer Cancers galectin serum breast neoplasm molecular subtype galectin-1 galectin-3 |
| title | Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer |
| title_full | Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer |
| title_fullStr | Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer |
| title_full_unstemmed | Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer |
| title_short | Pattern Analysis of Serum Galectins-1, -3, and -9 in Breast Cancer |
| title_sort | pattern analysis of serum galectins 1 3 and 9 in breast cancer |
| topic | galectin serum breast neoplasm molecular subtype galectin-1 galectin-3 |
| url | https://www.mdpi.com/2072-6694/15/15/3809 |
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