GH Responsiveness Is not Correlated to IGF1 P2 Promoter Methylation in Children With Turner Syndrome, GHD and SGA Short Stature

GH Responsiveness Is not Correlated to IGF1 P2 Promoter Methylation in Children With Turner Syndrome, GHD and SGA Short Stature

BackgroundThe methylation of IGF1 promoter P2 was reported to negatively correlate with serum IGF-1 concentration and rhGH treatment response in children with idiopathic short stature. These findings have not yet been confirmed.ObjectiveThis study aimed to determine IGF1 promoter P2 methylation in s...

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Bibliographic Details
Main Authors: Anja Apel, Daniel I. Iliev, Christina Urban, Karin Weber, Roland Schweizer, Gunnar Blumenstock, Sarah Pasche, Vanessa Nieratschker, Gerhard Binder
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
IGF-1
promotor methylation
GH response
prediction
short stature
GH treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.897897/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.897897/full

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