Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer’s disease, and cachexia. This is a critically important topic that has significance in the health of the current society, par...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2973 |
| _version_ | 1797624185471631360 |
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| author | Lauren Jun Megan Robinson Thangiah Geetha Tom L. Broderick Jeganathan Ramesh Babu |
| author_facet | Lauren Jun Megan Robinson Thangiah Geetha Tom L. Broderick Jeganathan Ramesh Babu |
| author_sort | Lauren Jun |
| collection | DOAJ |
| description | Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer’s disease, and cachexia. This is a critically important topic that has significance in the health of the current society, particularly older adults. The most damaging effect of muscle atrophy is the decreased quality of life from functional disability, increased risk of fractures, decreased basal metabolic rate, and reduced bone mineral density. Most skeletal muscle in humans contains slow oxidative, fast oxidative, and fast glycolytic muscle fiber types. Depending on the pathological condition, either oxidative or glycolytic muscle type may be affected to a greater extent. This review article discusses the prevalence of skeletal muscle atrophy and several mechanisms, with an emphasis on high-fat, high-sugar diet patterns, obesity, and diabetes, but including other conditions such as sarcopenia, Alzheimer’s disease, cancer cachexia, and heart failure. |
| first_indexed | 2024-03-11T09:39:27Z |
| format | Article |
| id | doaj.art-f4a6ecd208834e32a58f5ba9c1515c5c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:39:27Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4a6ecd208834e32a58f5ba9c1515c5c2023-11-16T17:05:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01243297310.3390/ijms24032973Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic ConditionsLauren Jun0Megan Robinson1Thangiah Geetha2Tom L. Broderick3Jeganathan Ramesh Babu4Department of Nutritional Sciences, Auburn University, Auburn, AL 36849, USADepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USADepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USADepartment of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USADepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USASkeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer’s disease, and cachexia. This is a critically important topic that has significance in the health of the current society, particularly older adults. The most damaging effect of muscle atrophy is the decreased quality of life from functional disability, increased risk of fractures, decreased basal metabolic rate, and reduced bone mineral density. Most skeletal muscle in humans contains slow oxidative, fast oxidative, and fast glycolytic muscle fiber types. Depending on the pathological condition, either oxidative or glycolytic muscle type may be affected to a greater extent. This review article discusses the prevalence of skeletal muscle atrophy and several mechanisms, with an emphasis on high-fat, high-sugar diet patterns, obesity, and diabetes, but including other conditions such as sarcopenia, Alzheimer’s disease, cancer cachexia, and heart failure.https://www.mdpi.com/1422-0067/24/3/2973skeletal musclemuscle atrophyobesitysarcopeniadiabetesAlzheimer’s disease |
| spellingShingle | Lauren Jun Megan Robinson Thangiah Geetha Tom L. Broderick Jeganathan Ramesh Babu Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions International Journal of Molecular Sciences skeletal muscle muscle atrophy obesity sarcopenia diabetes Alzheimer’s disease |
| title | Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions |
| title_full | Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions |
| title_fullStr | Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions |
| title_full_unstemmed | Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions |
| title_short | Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions |
| title_sort | prevalence and mechanisms of skeletal muscle atrophy in metabolic conditions |
| topic | skeletal muscle muscle atrophy obesity sarcopenia diabetes Alzheimer’s disease |
| url | https://www.mdpi.com/1422-0067/24/3/2973 |
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