Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
Purpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 sin...
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Format: | Article |
Language: | English |
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Korean Pediatric Society
2010-04-01
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Series: | Korean Journal of Pediatrics |
Online Access: | http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF |
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author | Hwan Hee Jung Won Ho Hahn Byoung Soo Cho Sung Do Kim |
author_facet | Hwan Hee Jung Won Ho Hahn Byoung Soo Cho Sung Do Kim |
author_sort | Hwan Hee Jung |
collection | DOAJ |
description | Purpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN. Methods : The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (< and >4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049; haplotype C/T: recessive model, P =0.030). Conclusion : Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population. |
first_indexed | 2024-12-11T18:50:03Z |
format | Article |
id | doaj.art-f4aced66160943859a6d609321abc026 |
institution | Directory Open Access Journal |
issn | 1738-1061 2092-7258 |
language | English |
last_indexed | 2024-12-11T18:50:03Z |
publishDate | 2010-04-01 |
publisher | Korean Pediatric Society |
record_format | Article |
series | Korean Journal of Pediatrics |
spelling | doaj.art-f4aced66160943859a6d609321abc0262022-12-22T00:54:20ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582010-04-0153454855310.3345/kjp.2010.53.4.548Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean populationHwan Hee JungWon Ho HahnByoung Soo ChoSung Do KimPurpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN. Methods : The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (< and >4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049; haplotype C/T: recessive model, P =0.030). Conclusion : Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population.http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF |
spellingShingle | Hwan Hee Jung Won Ho Hahn Byoung Soo Cho Sung Do Kim Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population Korean Journal of Pediatrics |
title | Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population |
title_full | Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population |
title_fullStr | Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population |
title_full_unstemmed | Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population |
title_short | Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population |
title_sort | association of hla g gene promoter haplotype with childhood iga nephropathy in the korean population |
url | http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF |
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