Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population

Purpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 sin...

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Main Authors: Hwan Hee Jung, Won Ho Hahn, Byoung Soo Cho, Sung Do Kim
Format: Article
Language:English
Published: Korean Pediatric Society 2010-04-01
Series:Korean Journal of Pediatrics
Online Access:http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF
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author Hwan Hee Jung
Won Ho Hahn
Byoung Soo Cho
Sung Do Kim
author_facet Hwan Hee Jung
Won Ho Hahn
Byoung Soo Cho
Sung Do Kim
author_sort Hwan Hee Jung
collection DOAJ
description Purpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN. Methods : The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (&amp&#59;lt&#59; and &amp&#59;gt&#59;4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049&#59; haplotype C/T: recessive model, P =0.030). Conclusion : Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population.
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spelling doaj.art-f4aced66160943859a6d609321abc0262022-12-22T00:54:20ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582010-04-0153454855310.3345/kjp.2010.53.4.548Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean populationHwan Hee JungWon Ho HahnByoung Soo ChoSung Do KimPurpose : IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN. Methods : The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (&amp&#59;lt&#59; and &amp&#59;gt&#59;4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049&#59; haplotype C/T: recessive model, P =0.030). Conclusion : Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population.http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF
spellingShingle Hwan Hee Jung
Won Ho Hahn
Byoung Soo Cho
Sung Do Kim
Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
Korean Journal of Pediatrics
title Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
title_full Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
title_fullStr Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
title_full_unstemmed Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
title_short Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
title_sort association of hla g gene promoter haplotype with childhood iga nephropathy in the korean population
url http://www.kjp.or.kr/upload/2010530413-20100644183044.PDF
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