Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs

Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs

The use of cell-penetrating peptides (CPPs) in combination with nanoparticles (NPs) shows great potential for intracellular delivery of DNA. Currently, its application is limited due to the potential toxicity and unknown long-term side effects. In this study NPs prepared using a biodegradable polyme...

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Bibliographic Details
Main Authors: Larissa Gomes dos Reis, Wing-Hin Lee, Maree Svolos, Lyn Margaret Moir, Rima Jaber, Norbert Windhab, Paul Michael Young, Daniela Traini
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
alveolar
bronchial
apoptosis
autophagy
gene delivery
Online Access:http://www.mdpi.com/1999-4923/11/1/12

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