Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition
The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also mod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-04-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/21739 |
| _version_ | 1818234320611966976 |
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| author | Meng Hang Fan Zhao Shu-Bo Chen Qing Sun Chun-Xiao Zhang |
| author_facet | Meng Hang Fan Zhao Shu-Bo Chen Qing Sun Chun-Xiao Zhang |
| author_sort | Meng Hang |
| collection | DOAJ |
| description | The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer. |
| first_indexed | 2024-12-12T11:36:12Z |
| format | Article |
| id | doaj.art-f4b00499e9674838b9e4673d55df51f5 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T11:36:12Z |
| publishDate | 2015-04-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f4b00499e9674838b9e4673d55df51f52022-12-22T00:25:39ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-04-0110210.3329/bjp.v10i2.21739Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transitionMeng Hang0Fan Zhao1Shu-Bo Chen2Qing Sun3Chun-Xiao Zhang4Department of Oncology, Jiangsu Province Wuxi No. 2 People?s Hospital, Wuxi 214002Department of Oncology, Jiangsu Province Wuxi No. 2 People?s Hospital, Wuxi 214002Department of Oncology, Jiangsu Province Wuxi No. 2 People?s Hospital, Wuxi 214002Department of Oncology, Jiangsu Province Wuxi No. 2 People?s Hospital, Wuxi 214002Department of Oncology, Jiangsu Province Wuxi No. 2 People?s Hospital, Wuxi 214002The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.https://www.banglajol.info/index.php/BJP/article/view/21739Epithelial-Mesenchymal TransitionKaempferolNon-small cell lung cancer |
| spellingShingle | Meng Hang Fan Zhao Shu-Bo Chen Qing Sun Chun-Xiao Zhang Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition Bangladesh Journal of Pharmacology Epithelial-Mesenchymal Transition Kaempferol Non-small cell lung cancer |
| title | Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition |
| title_full | Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition |
| title_fullStr | Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition |
| title_full_unstemmed | Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition |
| title_short | Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition |
| title_sort | kaempferol modulates the metastasis of human non small cell lung cancer cells by inhibiting epithelial mesenchymal transition |
| topic | Epithelial-Mesenchymal Transition Kaempferol Non-small cell lung cancer |
| url | https://www.banglajol.info/index.php/BJP/article/view/21739 |
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