DNA in extracellular vesicles: biological and clinical aspects
The study of extracellular vesicles (EVs), especially in the liquid biopsy field, has rapidly evolved in recent years. However, most EV studies have focused on RNA or protein content and DNA in EVs (EV‐DNA) has largely been unnoticed. In this review, we compile current evidence regarding EV‐DNA and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.12777 |
| _version_ | 1818611161967362048 |
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| author | Julia Elzanowska Christine Semira Bruno Costa‐Silva |
| author_facet | Julia Elzanowska Christine Semira Bruno Costa‐Silva |
| author_sort | Julia Elzanowska |
| collection | DOAJ |
| description | The study of extracellular vesicles (EVs), especially in the liquid biopsy field, has rapidly evolved in recent years. However, most EV studies have focused on RNA or protein content and DNA in EVs (EV‐DNA) has largely been unnoticed. In this review, we compile current evidence regarding EV‐DNA and provide an extensive discussion on EV‐DNA biology. We look into EV‐DNA biogenesis and mechanisms of DNA loading into EVs, as well as describe the particularly significant function of DNA‐carrying EVs in the maintenance of cellular homeostasis, intracellular communication, and immune response modulation. We also examine the current role of EV‐DNA in the clinical setting, specifically in cancer, infections, pregnancy, and prenatal diagnosis. |
| first_indexed | 2024-12-16T15:25:56Z |
| format | Article |
| id | doaj.art-f4b3192e29054ef2bc49d1e48a17582d |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-12-16T15:25:56Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-f4b3192e29054ef2bc49d1e48a17582d2022-12-21T22:26:31ZengWileyMolecular Oncology1574-78911878-02612021-06-011561701171410.1002/1878-0261.12777DNA in extracellular vesicles: biological and clinical aspectsJulia Elzanowska0Christine Semira1Bruno Costa‐Silva2Champalimaud Research Champalimaud Centre for the Unknown Lisbon PortugalChampalimaud Research Champalimaud Centre for the Unknown Lisbon PortugalChampalimaud Research Champalimaud Centre for the Unknown Lisbon PortugalThe study of extracellular vesicles (EVs), especially in the liquid biopsy field, has rapidly evolved in recent years. However, most EV studies have focused on RNA or protein content and DNA in EVs (EV‐DNA) has largely been unnoticed. In this review, we compile current evidence regarding EV‐DNA and provide an extensive discussion on EV‐DNA biology. We look into EV‐DNA biogenesis and mechanisms of DNA loading into EVs, as well as describe the particularly significant function of DNA‐carrying EVs in the maintenance of cellular homeostasis, intracellular communication, and immune response modulation. We also examine the current role of EV‐DNA in the clinical setting, specifically in cancer, infections, pregnancy, and prenatal diagnosis.https://doi.org/10.1002/1878-0261.12777cancercell‐free DNAEV‐DNAextracellular vesiclesinfectionliquid biopsies |
| spellingShingle | Julia Elzanowska Christine Semira Bruno Costa‐Silva DNA in extracellular vesicles: biological and clinical aspects Molecular Oncology cancer cell‐free DNA EV‐DNA extracellular vesicles infection liquid biopsies |
| title | DNA in extracellular vesicles: biological and clinical aspects |
| title_full | DNA in extracellular vesicles: biological and clinical aspects |
| title_fullStr | DNA in extracellular vesicles: biological and clinical aspects |
| title_full_unstemmed | DNA in extracellular vesicles: biological and clinical aspects |
| title_short | DNA in extracellular vesicles: biological and clinical aspects |
| title_sort | dna in extracellular vesicles biological and clinical aspects |
| topic | cancer cell‐free DNA EV‐DNA extracellular vesicles infection liquid biopsies |
| url | https://doi.org/10.1002/1878-0261.12777 |
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