Synthesis of 1-(2'-Deoxy-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]-pyridazine-4,7(5H,6H)-dione: A Potential Building Block for Antisense Applications

Synthesis of 1-(2'-Deoxy-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]-pyridazine-4,7(5H,6H)-dione: A Potential Building Block for Antisense Applications

Synthesis of the title compound,1-(2'-deoxy-b-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in five steps, commencing with methyl 1-(b-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 were protected with...

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Bibliographic Details
Main Authors: Ramachandra S. Hosmane, Huan-Ming Chen
Format: Article
Language:English
Published: MDPI AG 2000-12-01
Series:Molecules
Subjects:
Synthesis
Nucleoside Analogue
Imidazo[4
5-d]pyridazine
2'-Deoxy Nucleoside Analogue
Online Access:http://www.mdpi.com/1420-3049/5/12/1187/

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http://www.mdpi.com/1420-3049/5/12/1187/

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