Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome
The aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparableby age, sex ratio and BMI. T...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2015-08-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/6826 |
| _version_ | 1797204641431158784 |
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| author | Natalya Viktorovna Strueva Galina Afanas'evna Melnichenko Mikhail Gur'evich Poluektov Larisa Viktorovna Savel'eva Gulinara Viktorovna Katsya Nikolay Petrovich Goncharov |
| author_facet | Natalya Viktorovna Strueva Galina Afanas'evna Melnichenko Mikhail Gur'evich Poluektov Larisa Viktorovna Savel'eva Gulinara Viktorovna Katsya Nikolay Petrovich Goncharov |
| author_sort | Natalya Viktorovna Strueva |
| collection | DOAJ |
| description | The aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparableby age, sex ratio and BMI. The first group consisted of 41 patients with obstructive sleep apnea syndrome (OSAS), the second (controls) – 35 patients without breath disorders during sleep. OSAS is accompanied by the increase in urinary cortisol during the night, high levels ofbasal insulin, disturbances of hepatic production of IGF-1, dysfunction of the pituitary-gonadal axis. Our results show that sleep-related breathing disorders render markedly and negatively affect on hormonal parameters of patients with obesity. As a reliable difference of basalsecretion of orexin A in obese patients with and without OSAS was not revealed (42,0 [14; 99,5] vs. 18,0 [14,5; 124,5] pg/ml; р=0,9), we were not able to show the existence that the existence of OSAS is followed by any special changes of activity of the orexin system. |
| first_indexed | 2024-03-08T09:13:47Z |
| format | Article |
| id | doaj.art-f4b47ef05de74851b54100df0b036e1d |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:27Z |
| publishDate | 2015-08-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-f4b47ef05de74851b54100df0b036e1d2024-04-16T16:16:10ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242015-08-01122243010.14341/omet2015223-296788Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndromeNatalya Viktorovna Strueva0Galina Afanas'evna Melnichenko1Mikhail Gur'evich Poluektov2Larisa Viktorovna Savel'eva3Gulinara Viktorovna Katsya4Nikolay Petrovich Goncharov5Endocrinology Research CentreEndocrinology Research CentreI. M. Sechenov First Moscow State Medical UniversityEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreThe aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparableby age, sex ratio and BMI. The first group consisted of 41 patients with obstructive sleep apnea syndrome (OSAS), the second (controls) – 35 patients without breath disorders during sleep. OSAS is accompanied by the increase in urinary cortisol during the night, high levels ofbasal insulin, disturbances of hepatic production of IGF-1, dysfunction of the pituitary-gonadal axis. Our results show that sleep-related breathing disorders render markedly and negatively affect on hormonal parameters of patients with obesity. As a reliable difference of basalsecretion of orexin A in obese patients with and without OSAS was not revealed (42,0 [14; 99,5] vs. 18,0 [14,5; 124,5] pg/ml; р=0,9), we were not able to show the existence that the existence of OSAS is followed by any special changes of activity of the orexin system.https://www.omet-endojournals.ru/jour/article/view/6826obesityhormonesobstructive sleep apnea |
| spellingShingle | Natalya Viktorovna Strueva Galina Afanas'evna Melnichenko Mikhail Gur'evich Poluektov Larisa Viktorovna Savel'eva Gulinara Viktorovna Katsya Nikolay Petrovich Goncharov Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome Ожирение и метаболизм obesity hormones obstructive sleep apnea |
| title | Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| title_full | Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| title_fullStr | Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| title_full_unstemmed | Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| title_short | Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| title_sort | hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome |
| topic | obesity hormones obstructive sleep apnea |
| url | https://www.omet-endojournals.ru/jour/article/view/6826 |
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