Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review
Introduction: Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in expe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Universitas Muhammadiyah Surabaya
2021-07-01
|
| Series: | Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya |
| Subjects: | |
| Online Access: | http://journal.um-surabaya.ac.id/index.php/qanunmedika/article/view/6354 |
| _version_ | 1818656586561748992 |
|---|---|
| author | Nur Azizah AS Lysa Veterini Hafid Algristian Hotimah Masdan Salim |
| author_facet | Nur Azizah AS Lysa Veterini Hafid Algristian Hotimah Masdan Salim |
| author_sort | Nur Azizah AS |
| collection | DOAJ |
| description | Introduction: Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use.
Methods: This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles.
Results: The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005.
Conclusion: Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased. |
| first_indexed | 2024-12-17T03:27:56Z |
| format | Article |
| id | doaj.art-f4b7d0a9600745d898f6257dc6ce6850 |
| institution | Directory Open Access Journal |
| issn | 2541-2272 2548-9526 |
| language | Indonesian |
| last_indexed | 2024-12-17T03:27:56Z |
| publishDate | 2021-07-01 |
| publisher | Universitas Muhammadiyah Surabaya |
| record_format | Article |
| series | Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya |
| spelling | doaj.art-f4b7d0a9600745d898f6257dc6ce68502022-12-21T22:05:21ZindUniversitas Muhammadiyah SurabayaQanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya2541-22722548-95262021-07-015210.30651/jqm.v5i2.63543455Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature ReviewNur Azizah AS0Lysa Veterini1Hafid Algristian2Hotimah Masdan Salim3Unusa UniversityUnusa UniversityUnusa UniversityUnusa UniversityIntroduction: Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use. Methods: This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles. Results: The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005. Conclusion: Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased.http://journal.um-surabaya.ac.id/index.php/qanunmedika/article/view/6354chronic depression, stress, brain derived neurotrophic factor, bdnf, systematic literature review |
| spellingShingle | Nur Azizah AS Lysa Veterini Hafid Algristian Hotimah Masdan Salim Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya chronic depression, stress, brain derived neurotrophic factor, bdnf, systematic literature review |
| title | Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review |
| title_full | Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review |
| title_fullStr | Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review |
| title_full_unstemmed | Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review |
| title_short | Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review |
| title_sort | expression of brain derived neurotrophic factor in the brain of depressed mice systematic literature review |
| topic | chronic depression, stress, brain derived neurotrophic factor, bdnf, systematic literature review |
| url | http://journal.um-surabaya.ac.id/index.php/qanunmedika/article/view/6354 |
| work_keys_str_mv | AT nurazizahas expressionofbrainderivedneurotrophicfactorinthebrainofdepressedmicesystematicliteraturereview AT lysaveterini expressionofbrainderivedneurotrophicfactorinthebrainofdepressedmicesystematicliteraturereview AT hafidalgristian expressionofbrainderivedneurotrophicfactorinthebrainofdepressedmicesystematicliteraturereview AT hotimahmasdansalim expressionofbrainderivedneurotrophicfactorinthebrainofdepressedmicesystematicliteraturereview |