Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma
Patients with hereditary retinoblastoma have a heightened risk of developing subsequent bone and soft tissue sarcomas, exacerbated by radiation and alkylating chemotherapy. Secondary leiomyosarcomas are rare. A 29-year-old patient with bilateral retinoblastoma history presented with concurrent, inde...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/968567 |
| _version_ | 1798044817392926720 |
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| author | Katherine Moore Ossama Tawfik Allyson Hays Isaac Opole |
| author_facet | Katherine Moore Ossama Tawfik Allyson Hays Isaac Opole |
| author_sort | Katherine Moore |
| collection | DOAJ |
| description | Patients with hereditary retinoblastoma have a heightened risk of developing subsequent bone and soft tissue sarcomas, exacerbated by radiation and alkylating chemotherapy. Secondary leiomyosarcomas are rare. A 29-year-old patient with bilateral retinoblastoma history presented with concurrent, independent malignancies found to be Rb-suppressed uterine and Rb-positive bladder leiomyosarcomas. She had undergone both ifosfamide chemotherapy and radiation therapy but demonstrated rare simultaneous primary leiomyosarcomas not previously described in association with ifosfamide. This rare case underlines the protean genetic predisposition to malignancy in this patient population, heightening awareness of lifelong malignancy potential, and the necessity for continuous periodic screening. |
| first_indexed | 2024-04-11T23:10:23Z |
| format | Article |
| id | doaj.art-f4bbaf892eb94ba2b40ca5102c980797 |
| institution | Directory Open Access Journal |
| issn | 2090-6706 2090-6714 |
| language | English |
| last_indexed | 2024-04-11T23:10:23Z |
| publishDate | 2015-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj.art-f4bbaf892eb94ba2b40ca5102c9807972022-12-22T03:57:53ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/968567968567Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary RetinoblastomaKatherine Moore0Ossama Tawfik1Allyson Hays2Isaac Opole3Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Hematology/Oncology, Children’s Mercy Hospital, Kansas City, MO 64108, USADepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USAPatients with hereditary retinoblastoma have a heightened risk of developing subsequent bone and soft tissue sarcomas, exacerbated by radiation and alkylating chemotherapy. Secondary leiomyosarcomas are rare. A 29-year-old patient with bilateral retinoblastoma history presented with concurrent, independent malignancies found to be Rb-suppressed uterine and Rb-positive bladder leiomyosarcomas. She had undergone both ifosfamide chemotherapy and radiation therapy but demonstrated rare simultaneous primary leiomyosarcomas not previously described in association with ifosfamide. This rare case underlines the protean genetic predisposition to malignancy in this patient population, heightening awareness of lifelong malignancy potential, and the necessity for continuous periodic screening.http://dx.doi.org/10.1155/2015/968567 |
| spellingShingle | Katherine Moore Ossama Tawfik Allyson Hays Isaac Opole Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma Case Reports in Oncological Medicine |
| title | Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma |
| title_full | Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma |
| title_fullStr | Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma |
| title_full_unstemmed | Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma |
| title_short | Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma |
| title_sort | simultaneous low and high grade primary leiomyosarcomas in two separate organs in a thirty year survivor of hereditary retinoblastoma |
| url | http://dx.doi.org/10.1155/2015/968567 |
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