Pathophysiology of meningioma growth in pregnancy
Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2017-07-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2017-0029 |
| _version_ | 1819117627050557440 |
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| author | Hortobágyi Tibor Bencze János Murnyák Balázs Kouhsari Mahan C. Bognár László Marko-Varga György |
| author_facet | Hortobágyi Tibor Bencze János Murnyák Balázs Kouhsari Mahan C. Bognár László Marko-Varga György |
| author_sort | Hortobágyi Tibor |
| collection | DOAJ |
| description | Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy. |
| first_indexed | 2024-12-22T05:35:59Z |
| format | Article |
| id | doaj.art-f4bc9e7739c042cba5b0e265d5e472c1 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-22T05:35:59Z |
| publishDate | 2017-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-f4bc9e7739c042cba5b0e265d5e472c12022-12-21T18:37:19ZengDe GruyterOpen Medicine2391-54632017-07-0112119520010.1515/med-2017-0029med-2017-0029Pathophysiology of meningioma growth in pregnancyHortobágyi Tibor0Bencze János1Murnyák Balázs2Kouhsari Mahan C.3Bognár László4Marko-Varga György5Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Nagyerdei krt. 98., H-4032, HungaryDivision of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDivision of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDivision of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Neurosurgery, University of Debrecen Clinical Center, Debrecen, HungaryDivision of Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University, Lund, SwedenMeningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy.https://doi.org/10.1515/med-2017-0029meningiomapregnancypathophysiologyendocrinologyhemodynamics |
| spellingShingle | Hortobágyi Tibor Bencze János Murnyák Balázs Kouhsari Mahan C. Bognár László Marko-Varga György Pathophysiology of meningioma growth in pregnancy Open Medicine meningioma pregnancy pathophysiology endocrinology hemodynamics |
| title | Pathophysiology of meningioma growth in pregnancy |
| title_full | Pathophysiology of meningioma growth in pregnancy |
| title_fullStr | Pathophysiology of meningioma growth in pregnancy |
| title_full_unstemmed | Pathophysiology of meningioma growth in pregnancy |
| title_short | Pathophysiology of meningioma growth in pregnancy |
| title_sort | pathophysiology of meningioma growth in pregnancy |
| topic | meningioma pregnancy pathophysiology endocrinology hemodynamics |
| url | https://doi.org/10.1515/med-2017-0029 |
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