Copy Number of an Integron-Encoded Antibiotic Resistance Locus Regulates a Virulence and Opacity Switch in <named-content content-type="genus-species">Acinetobacter baumannii</named-content> AB5075

Copy Number of an Integron-Encoded Antibiotic Resistance Locus Regulates a Virulence and Opacity Switch in <named-content content-type="genus-species">Acinetobacter baumannii</named-content> AB5075

ABSTRACT We describe a novel genetic mechanism in which tandem amplification of a plasmid-borne integron regulates virulence, opacity variation, and global gene expression by altering levels of a putative small RNA (sRNA) in Acinetobacter baumannii AB5075. Copy number of this amplified locus correla...

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Bibliographic Details
Main Authors: Sarah E. Anderson, Chui Yoke Chin, David S. Weiss, Philip N. Rather
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
Acinetobacter
phenotypic switching
integron
sRNA
virulence regulation
Online Access:https://journals.asm.org/doi/10.1128/mBio.02338-20

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