Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus

CD4+ T cells develop distinct and often contrasting helper, regulatory, or cytotoxic activities. Typically a property of CD8+ T cells, granzyme-mediated cytotoxic T cell (CTL) potential is also exerted by CD4+ T cells. However, the conditions that induce CD4+ CTLs are not entirely understood. Using...

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Bibliographic Details
Main Authors: Tiziano Donnarumma, George R. Young, Julia Merkenschlager, Urszula Eksmond, Nadine Bongard, Stephen L. Nutt, Claude Boyer, Ulf Dittmer, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Wibke Bayer, George Kassiotis
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
cytotoxic CD4 T cells
retroviral infection
adenovirus-based vaccination
single-cell RNA sequencing
inhibitory receptors
CD4 T cell differentiation
antiviral immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313997

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