The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people
Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on meta...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2020-09-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-12-185.pdf |
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| author | Nahid Ramezani-Jolfaie Shiva Aghaei Ehsan Farashahi Yazd Ali Moradi Hassan Mozaffari-Khosravi Mojgan Amiri Hamidreza Raeisi-Dehkordi Fatemeh Moghtaderi Alireza Zimorovat Seyed Ali Yasini Ardakani Amin Salehi-Abargouei |
| author_facet | Nahid Ramezani-Jolfaie Shiva Aghaei Ehsan Farashahi Yazd Ali Moradi Hassan Mozaffari-Khosravi Mojgan Amiri Hamidreza Raeisi-Dehkordi Fatemeh Moghtaderi Alireza Zimorovat Seyed Ali Yasini Ardakani Amin Salehi-Abargouei |
| author_sort | Nahid Ramezani-Jolfaie |
| collection | DOAJ |
| description | Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind cross over trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-weekof the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1,and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results. |
| first_indexed | 2024-12-16T21:24:36Z |
| format | Article |
| id | doaj.art-f4c2be3cadbf4427b1de97e08996c503 |
| institution | Directory Open Access Journal |
| issn | 2008-5117 2008-6830 |
| language | English |
| last_indexed | 2024-12-16T21:24:36Z |
| publishDate | 2020-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj.art-f4c2be3cadbf4427b1de97e08996c5032022-12-21T22:15:48ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302020-09-0112318519410.34172/jcvtr.2020.32jcvtr-28809The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy peopleNahid Ramezani-Jolfaie0Shiva Aghaei1Ehsan Farashahi Yazd2Ali Moradi3Hassan Mozaffari-Khosravi4Mojgan Amiri5Hamidreza Raeisi-Dehkordi6Fatemeh Moghtaderi7Alireza Zimorovat8Seyed Ali Yasini Ardakani9Amin Salehi-Abargouei10Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranStem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, IranStem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Food Science and Technology, Islamic Azad University, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranIntroduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind cross over trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-weekof the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1,and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-12-185.pdfcholesterol ester transfer proteinsdiabetes mellitussesame oilcanola oilsesame-canola oilpolymorphism |
| spellingShingle | Nahid Ramezani-Jolfaie Shiva Aghaei Ehsan Farashahi Yazd Ali Moradi Hassan Mozaffari-Khosravi Mojgan Amiri Hamidreza Raeisi-Dehkordi Fatemeh Moghtaderi Alireza Zimorovat Seyed Ali Yasini Ardakani Amin Salehi-Abargouei The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people Journal of Cardiovascular and Thoracic Research cholesterol ester transfer proteins diabetes mellitus sesame oil canola oil sesame-canola oil polymorphism |
| title | The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people |
| title_full | The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people |
| title_fullStr | The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people |
| title_full_unstemmed | The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people |
| title_short | The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people |
| title_sort | combined effects of cholesteryl ester transfer protein cetp taqib gene polymorphism and canola sesame and sesame canola oils consumption on metabolic response in patients with diabetes and healthy people |
| topic | cholesterol ester transfer proteins diabetes mellitus sesame oil canola oil sesame-canola oil polymorphism |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-12-185.pdf |
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