Development and validation of a 6-plex Luminex-based assay for measuring human serum antibodies to group B streptococcus capsular polysaccharides

Development and validation of a 6-plex Luminex-based assay for measuring human serum antibodies to group B streptococcus capsular polysaccharides

ABSTRACTSix serotypes (Ia, Ib, II, III, IV, and V) cause nearly all group B streptococcal (GBS) disease globally. Capsular polysaccharide (CPS) conjugate vaccines aim to prevent GBS disease, however, licensure of a vaccine would depend on a standardized serological assay for measuring anti-CPS IgG r...

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Bibliographic Details
Main Authors: Michelle A. Gaylord, Melissa Larrier, Donna Giordano-Schmidt, Christopher D. Grube, Suddham Singh, Ha H. Nguyen, Andrew McKeen, Charles Y. Tan, Annaliesa S. Anderson, Warren V. Kalina, Danka Pavliakova, Peter C. Giardina
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Streptococcus agalactiae
group B streptococcus
capsular polysaccharide
serotype
immunoassay
IgG
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2311480

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