CNS Macrophages Control Neurovascular Development via CD95L
The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions, including the morphogenesis of neurons and vesse...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-05-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717305673 |
| _version_ | 1811238277658705920 |
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| author | Si Chen Nathalie Tisch Marcel Kegel Rosario Yerbes Robert Hermann Hannes Hudalla Cecilia Zuliani Gülce Sila Gülcüler Klara Zwadlo Jakob von Engelhardt Carmen Ruiz de Almodóvar Ana Martin-Villalba |
| author_facet | Si Chen Nathalie Tisch Marcel Kegel Rosario Yerbes Robert Hermann Hannes Hudalla Cecilia Zuliani Gülce Sila Gülcüler Klara Zwadlo Jakob von Engelhardt Carmen Ruiz de Almodóvar Ana Martin-Villalba |
| author_sort | Si Chen |
| collection | DOAJ |
| description | The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions, including the morphogenesis of neurons and vessels. However, whether CNS macrophages can coordinately influence neurovascular development and the identity of the signals involved therein is unclear. Here, we demonstrate that activity of the cell surface receptor CD95 regulates neuronal and vascular morphogenesis in the post-natal brain and retina. Furthermore, we identify CNS macrophages as the main source of CD95L, and macrophage-specific deletion thereof reduces both neurovascular complexity and synaptic activity in the brain. CD95L-induced neuronal and vascular growth is mediated through src-family kinase (SFK) and PI3K signaling. Together, our study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L, and it underlines the importance of macrophages for the establishment of the neurovascular network during CNS development. |
| first_indexed | 2024-04-12T12:40:07Z |
| format | Article |
| id | doaj.art-f4c6c6f6c1234f02b796243e1b5ae530 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-12T12:40:07Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f4c6c6f6c1234f02b796243e1b5ae5302022-12-22T03:32:49ZengElsevierCell Reports2211-12472017-05-011971378139310.1016/j.celrep.2017.04.056CNS Macrophages Control Neurovascular Development via CD95LSi Chen0Nathalie Tisch1Marcel Kegel2Rosario Yerbes3Robert Hermann4Hannes Hudalla5Cecilia Zuliani6Gülce Sila Gülcüler7Klara Zwadlo8Jakob von Engelhardt9Carmen Ruiz de Almodóvar10Ana Martin-Villalba11Department of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyBiochemistry Center, Heidelberg University, 69120 Heidelberg, GermanyInstitute of Pathophysiology, University Medical Center of Johannes Gutenberg University Mainz, 55131 Mainz, GermanyBiochemistry Center, Heidelberg University, 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyInstitute of Pathophysiology, University Medical Center of Johannes Gutenberg University Mainz, 55131 Mainz, GermanyBiochemistry Center, Heidelberg University, 69120 Heidelberg, GermanyDepartment of Molecular Neurobiology, German Cancer Research Center (DFKZ), 69120 Heidelberg, GermanyThe development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions, including the morphogenesis of neurons and vessels. However, whether CNS macrophages can coordinately influence neurovascular development and the identity of the signals involved therein is unclear. Here, we demonstrate that activity of the cell surface receptor CD95 regulates neuronal and vascular morphogenesis in the post-natal brain and retina. Furthermore, we identify CNS macrophages as the main source of CD95L, and macrophage-specific deletion thereof reduces both neurovascular complexity and synaptic activity in the brain. CD95L-induced neuronal and vascular growth is mediated through src-family kinase (SFK) and PI3K signaling. Together, our study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L, and it underlines the importance of macrophages for the establishment of the neurovascular network during CNS development.http://www.sciencedirect.com/science/article/pii/S2211124717305673CNS macrophagesmicroglianeurovascular developmentvesselangiogenesisCD95CD95Lcortexretina |
| spellingShingle | Si Chen Nathalie Tisch Marcel Kegel Rosario Yerbes Robert Hermann Hannes Hudalla Cecilia Zuliani Gülce Sila Gülcüler Klara Zwadlo Jakob von Engelhardt Carmen Ruiz de Almodóvar Ana Martin-Villalba CNS Macrophages Control Neurovascular Development via CD95L Cell Reports CNS macrophages microglia neurovascular development vessel angiogenesis CD95 CD95L cortex retina |
| title | CNS Macrophages Control Neurovascular Development via CD95L |
| title_full | CNS Macrophages Control Neurovascular Development via CD95L |
| title_fullStr | CNS Macrophages Control Neurovascular Development via CD95L |
| title_full_unstemmed | CNS Macrophages Control Neurovascular Development via CD95L |
| title_short | CNS Macrophages Control Neurovascular Development via CD95L |
| title_sort | cns macrophages control neurovascular development via cd95l |
| topic | CNS macrophages microglia neurovascular development vessel angiogenesis CD95 CD95L cortex retina |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717305673 |
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