Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level
The purpose of this study is to investigate the effects of different concentrations of Rhododendron honey (RH) on mouse cardiac muscle lipids by Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy at molecular level. For this purpose, a total of eighteen male Mus musculus...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2019-11-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=2666 |
| _version_ | 1797800744472018944 |
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| author | Gulgun CAKMAK ARSLAN Selin EMIR Pinar GOC RASGELE Meral KEKECOGLU |
| author_facet | Gulgun CAKMAK ARSLAN Selin EMIR Pinar GOC RASGELE Meral KEKECOGLU |
| author_sort | Gulgun CAKMAK ARSLAN |
| collection | DOAJ |
| description | The purpose of this study is to investigate the effects of different concentrations of Rhododendron honey (RH) on mouse cardiac muscle lipids
by Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy at molecular level. For this purpose, a total of eighteen
male Mus musculus mice were divided into three groups of six animals each, one being the control group and the others being the 25 and 50
mg/kg of RH-treated groups. RH was given via gavage and the cardiac muscles of these mice were investigated 24 h after the administration.
The results revealed that 25 mg/kg of RH did not cause any significant effect except lipid peroxidation. However, 50 mg/kg RH caused
increases in the amounts of saturated and unsaturated lipids, in the ratios of lipid/protein and CH2/CH3 and a decrease in the CH3/lipid which
all indicate a change in the lipid metabolism of the tissue. Moreover, the treatment with 50 mg/kg of RH caused lipid peroxidation, a decrease
in lipid order and an increase in membrane dynamic. These results revealed that RH causes significant toxic effects on cardiac muscle tissue
lipids and these effects are dose-dependent. |
| first_indexed | 2024-03-13T04:38:52Z |
| format | Article |
| id | doaj.art-f4c86616f89546d4bd26f8154ae7cfd4 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:38:52Z |
| publishDate | 2019-11-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-f4c86616f89546d4bd26f8154ae7cfd42023-06-19T06:33:04ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512019-11-0126228729410.9775/kvfd.2019.229962666Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular levelGulgun CAKMAK ARSLAN0Selin EMIR1Pinar GOC RASGELE2Meral KEKECOGLUDepartment of Biology, Faculty of Arts and Sciences, Duzce University, TR-81620 Duzce - TURKEYDepartment of Biology, Faculty of Arts and Sciences, Duzce University, TR-81620 Duzce - TURKEYDepartment of Biosystems Engineering, Faculty of Agriculture and Natural Sciences, Duzce University, TR-81620 Duzce - TURKEYThe purpose of this study is to investigate the effects of different concentrations of Rhododendron honey (RH) on mouse cardiac muscle lipids by Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy at molecular level. For this purpose, a total of eighteen male Mus musculus mice were divided into three groups of six animals each, one being the control group and the others being the 25 and 50 mg/kg of RH-treated groups. RH was given via gavage and the cardiac muscles of these mice were investigated 24 h after the administration. The results revealed that 25 mg/kg of RH did not cause any significant effect except lipid peroxidation. However, 50 mg/kg RH caused increases in the amounts of saturated and unsaturated lipids, in the ratios of lipid/protein and CH2/CH3 and a decrease in the CH3/lipid which all indicate a change in the lipid metabolism of the tissue. Moreover, the treatment with 50 mg/kg of RH caused lipid peroxidation, a decrease in lipid order and an increase in membrane dynamic. These results revealed that RH causes significant toxic effects on cardiac muscle tissue lipids and these effects are dose-dependent.https://vetdergikafkas.org/pdf.php?id=2666rhododendron honeymad honeyatr-ftir spectroscopyheartcardiac musclelipid |
| spellingShingle | Gulgun CAKMAK ARSLAN Selin EMIR Pinar GOC RASGELE Meral KEKECOGLU Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level Kafkas Universitesi Veteriner Fakültesi Dergisi rhododendron honey mad honey atr-ftir spectroscopy heart cardiac muscle lipid |
| title | Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| title_full | Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| title_fullStr | Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| title_full_unstemmed | Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| title_short | Investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| title_sort | investigation of the toxic effects of rhododendron honey on mouse cardiac muscle tissue lipids at molecular level |
| topic | rhododendron honey mad honey atr-ftir spectroscopy heart cardiac muscle lipid |
| url | https://vetdergikafkas.org/pdf.php?id=2666 |
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