Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro
Anthocyanin-rich foods have shown potential health benefits. The objective was to evaluate the anti-proliferative effect of anthocyanin-rich purple and red corn on HCT-116 and HT-29 human colorectal cancer cells. IC50 values ranged from 1.1 to 6.3 mg/mL, suggesting the corn extracts exhibited anti-p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617302281 |
| _version_ | 1818415814312722432 |
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| author | Candice Mazewski Katie Liang Elvira Gonzalez de Mejia |
| author_facet | Candice Mazewski Katie Liang Elvira Gonzalez de Mejia |
| author_sort | Candice Mazewski |
| collection | DOAJ |
| description | Anthocyanin-rich foods have shown potential health benefits. The objective was to evaluate the anti-proliferative effect of anthocyanin-rich purple and red corn on HCT-116 and HT-29 human colorectal cancer cells. IC50 values ranged from 1.1 to 6.3 mg/mL, suggesting the corn extracts exhibited anti-proliferative effects on colon cancer cells; the red corn had the highest potential. All extracts increased apoptotic cells and impacted markers of apoptosis (BAX, Bcl-2, cytochrome c, TRAILR2/D5). Angiogenesis markers were also affected; a decreased expression of VEGF resulted with all corn extracts. Red corn significantly reduced other important markers of angiogenesis like Tie-2. Free binding energy of anthocyanins to tyrosine kinases was estimated at −7.86 and −7.76 kcal/mol for cyanidin-3-glucoside with a non-receptor tyrosine kinase and peonidin with a receptor tyrosine kinase, respectively. The results indicate that anthocyanin-rich purple and red corn can potentially inhibit human colon cancer cell proliferation through promoting apoptosis and suppressing angiogenesis. |
| first_indexed | 2024-12-14T11:40:58Z |
| format | Article |
| id | doaj.art-f4cbd59730394e598560d1407ff47502 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:40:58Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f4cbd59730394e598560d1407ff475022022-12-21T23:02:51ZengElsevierJournal of Functional Foods1756-46462017-07-0134254265Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitroCandice Mazewski0Katie Liang1Elvira Gonzalez de Mejia2Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 228 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USADepartment of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Justin Smith Morrill Hall, 505 S Goodwin Ave #393, Urbana, IL 61801, USADepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 228 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA; Corresponding author.Anthocyanin-rich foods have shown potential health benefits. The objective was to evaluate the anti-proliferative effect of anthocyanin-rich purple and red corn on HCT-116 and HT-29 human colorectal cancer cells. IC50 values ranged from 1.1 to 6.3 mg/mL, suggesting the corn extracts exhibited anti-proliferative effects on colon cancer cells; the red corn had the highest potential. All extracts increased apoptotic cells and impacted markers of apoptosis (BAX, Bcl-2, cytochrome c, TRAILR2/D5). Angiogenesis markers were also affected; a decreased expression of VEGF resulted with all corn extracts. Red corn significantly reduced other important markers of angiogenesis like Tie-2. Free binding energy of anthocyanins to tyrosine kinases was estimated at −7.86 and −7.76 kcal/mol for cyanidin-3-glucoside with a non-receptor tyrosine kinase and peonidin with a receptor tyrosine kinase, respectively. The results indicate that anthocyanin-rich purple and red corn can potentially inhibit human colon cancer cell proliferation through promoting apoptosis and suppressing angiogenesis.http://www.sciencedirect.com/science/article/pii/S1756464617302281AngiogenesisAnthocyaninsApoptosisColon cancerCornPigments |
| spellingShingle | Candice Mazewski Katie Liang Elvira Gonzalez de Mejia Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro Journal of Functional Foods Angiogenesis Anthocyanins Apoptosis Colon cancer Corn Pigments |
| title | Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| title_full | Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| title_fullStr | Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| title_full_unstemmed | Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| title_short | Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| title_sort | inhibitory potential of anthocyanin rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro |
| topic | Angiogenesis Anthocyanins Apoptosis Colon cancer Corn Pigments |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617302281 |
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