Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function

Objective: The prevalence of gene promoter polymorphism eNOS T786С and its relationship with the level of lipids and vascular endothelial function in patients with pseudoarthrosis of long bones was investigated. Materials and methods. In 118 patients with pseudoarthrosis of long bones frequency of m...

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Main Author: Bezsmertnyi Yu.O.
Format: Article
Language:English
Published: Dnipro State Medical University 2013-06-01
Series:Medičnì Perspektivi
Subjects:
Online Access:http://medpers.dsma.dp.ua/issues/2013/N2/73-78.pdf
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author Bezsmertnyi Yu.O.
author_facet Bezsmertnyi Yu.O.
author_sort Bezsmertnyi Yu.O.
collection DOAJ
description Objective: The prevalence of gene promoter polymorphism eNOS T786С and its relationship with the level of lipids and vascular endothelial function in patients with pseudoarthrosis of long bones was investigated. Materials and methods. In 118 patients with pseudoarthrosis of long bones frequency of mutation of gene promoter eNOS T786C was studied and its relationship to lipid levels and vascular endothelial function was determined. The control group consisted of 48 patients with consolidated diaphyseal fractures, representative by age, gender and location of the damage. Results and discussion. Pathological homozygotes eNOS 786-CC accumulate predominantly in patients with hypoplastic and atrophic type of pseudoarthrosis. The frequency of genotypes distribution in patients with normoplastic type of pseudoarthrosis corresponded to the same in people with consolidated fractures. In patients with genotype eNOS 786-CC more often individuals with aberrant lipid levels and structural and functional changes in the common carotid, brachial and femoral arteries are identified. Conclusions. In patients with pseudarthrosis of long bones tendency to decrease in the proportion of normal homozygotes (786-CT), increase in heterozygotes (786-CT) and the proportion of individuals with abnormal genotype 786-CC is observed. The mutation in gene T786C eNOS was associated with the development of hypoplastic and aplastic types of pseudarthrosis, increasing the proportion of persons with aberrant lipid levels, endothelial dysfunction of the central and peripheral vessels.
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spelling doaj.art-f4ce4916d6a8412da988fae6a2cbe52d2022-12-21T17:17:18ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042013-06-011827378Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial functionBezsmertnyi Yu.O. 0Institute of Rehabilitation, Vinnitsa national medical university M.I. PirogovObjective: The prevalence of gene promoter polymorphism eNOS T786С and its relationship with the level of lipids and vascular endothelial function in patients with pseudoarthrosis of long bones was investigated. Materials and methods. In 118 patients with pseudoarthrosis of long bones frequency of mutation of gene promoter eNOS T786C was studied and its relationship to lipid levels and vascular endothelial function was determined. The control group consisted of 48 patients with consolidated diaphyseal fractures, representative by age, gender and location of the damage. Results and discussion. Pathological homozygotes eNOS 786-CC accumulate predominantly in patients with hypoplastic and atrophic type of pseudoarthrosis. The frequency of genotypes distribution in patients with normoplastic type of pseudoarthrosis corresponded to the same in people with consolidated fractures. In patients with genotype eNOS 786-CC more often individuals with aberrant lipid levels and structural and functional changes in the common carotid, brachial and femoral arteries are identified. Conclusions. In patients with pseudarthrosis of long bones tendency to decrease in the proportion of normal homozygotes (786-CT), increase in heterozygotes (786-CT) and the proportion of individuals with abnormal genotype 786-CC is observed. The mutation in gene T786C eNOS was associated with the development of hypoplastic and aplastic types of pseudarthrosis, increasing the proportion of persons with aberrant lipid levels, endothelial dysfunction of the central and peripheral vessels.http://medpers.dsma.dp.ua/issues/2013/N2/73-78.pdfmutation eNOS T786Сpseudoarthrosislipidsendothelial function
spellingShingle Bezsmertnyi Yu.O.
Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
Medičnì Perspektivi
mutation eNOS T786С
pseudoarthrosis
lipids
endothelial function
title Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
title_full Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
title_fullStr Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
title_full_unstemmed Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
title_short Mutation of the gene promoter synthase nitric oxide eNOS T786С in patients with pseudarthrosis of long bones: relationship with lipid levels and endothelial function
title_sort mutation of the gene promoter synthase nitric oxide enos t786с in patients with pseudarthrosis of long bones relationship with lipid levels and endothelial function
topic mutation eNOS T786С
pseudoarthrosis
lipids
endothelial function
url http://medpers.dsma.dp.ua/issues/2013/N2/73-78.pdf
work_keys_str_mv AT bezsmertnyiyuo mutationofthegenepromotersynthasenitricoxideenost786sinpatientswithpseudarthrosisoflongbonesrelationshipwithlipidlevelsandendothelialfunction