Humanizing the yeast origin recognition complex
In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20277-y |
| _version_ | 1818684247631724544 |
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| author | Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye |
| author_facet | Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye |
| author_sort | Clare S. K. Lee |
| collection | DOAJ |
| description | In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertion helix in the Orc4 subunit which is lost in human. |
| first_indexed | 2024-12-17T10:47:36Z |
| format | Article |
| id | doaj.art-f4ce881c9d4e4808a3ce45ff1501fdd0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:47:36Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f4ce881c9d4e4808a3ce45ff1501fdd02022-12-21T21:52:04ZengNature PortfolioNature Communications2041-17232021-01-0112111110.1038/s41467-020-20277-yHumanizing the yeast origin recognition complexClare S. K. Lee0Ming Fung Cheung1Jinsen Li2Yongqian Zhao3Wai Hei Lam4Vincy Ho5Remo Rohs6Yuanliang Zhai7Danny Leung8Bik-Kwoon Tye9School of Biological Sciences, The University of Hong KongCenter for Epigenomics Research, The Hong Kong University of Science & TechnologyQuantitative and Computational Biology, Departments of Biological Sciences, Chemistry, Physics & Astronomy, and Computer Science, University of Southern CaliforniaDivision of Life Science, The Hong Kong University of Science & TechnologySchool of Biological Sciences, The University of Hong KongCenter for Epigenomics Research, The Hong Kong University of Science & TechnologyQuantitative and Computational Biology, Departments of Biological Sciences, Chemistry, Physics & Astronomy, and Computer Science, University of Southern CaliforniaSchool of Biological Sciences, The University of Hong KongCenter for Epigenomics Research, The Hong Kong University of Science & TechnologyDivision of Life Science, The Hong Kong University of Science & TechnologyIn most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertion helix in the Orc4 subunit which is lost in human.https://doi.org/10.1038/s41467-020-20277-y |
| spellingShingle | Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye Humanizing the yeast origin recognition complex Nature Communications |
| title | Humanizing the yeast origin recognition complex |
| title_full | Humanizing the yeast origin recognition complex |
| title_fullStr | Humanizing the yeast origin recognition complex |
| title_full_unstemmed | Humanizing the yeast origin recognition complex |
| title_short | Humanizing the yeast origin recognition complex |
| title_sort | humanizing the yeast origin recognition complex |
| url | https://doi.org/10.1038/s41467-020-20277-y |
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