Mouse rods signal through gap junctions with cones
Rod and cone photoreceptors are coupled by gap junctions (GJs), relatively large channels able to mediate both electrical and molecular communication. Despite their critical location in our visual system and evidence that they are dynamically gated for dark/light adaptation, the full impact that rod...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01386 |
| _version_ | 1818028284113321984 |
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| author | Sabrina Asteriti Claudia Gargini Lorenzo Cangiano |
| author_facet | Sabrina Asteriti Claudia Gargini Lorenzo Cangiano |
| author_sort | Sabrina Asteriti |
| collection | DOAJ |
| description | Rod and cone photoreceptors are coupled by gap junctions (GJs), relatively large channels able to mediate both electrical and molecular communication. Despite their critical location in our visual system and evidence that they are dynamically gated for dark/light adaptation, the full impact that rod–cone GJs can have on cone function is not known. We recorded the photovoltage of mouse cones and found that the initial level of rod input increased spontaneously after obtaining intracellular access. This process allowed us to explore the underlying coupling capacity to rods, revealing that fully coupled cones acquire a striking rod-like phenotype. Calcium, a candidate mediator of the coupling process, does not appear to be involved on the cone side of the junctional channels. Our findings show that the anatomical substrate is adequate for rod–cone coupling to play an important role in vision and, possibly, in biochemical signaling among photoreceptors. |
| first_indexed | 2024-12-10T05:01:21Z |
| format | Article |
| id | doaj.art-f4cef815bea342c0b9afa68cd9671f23 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T05:01:21Z |
| publishDate | 2014-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f4cef815bea342c0b9afa68cd9671f232022-12-22T02:01:23ZengeLife Sciences Publications LtdeLife2050-084X2014-01-01310.7554/eLife.01386Mouse rods signal through gap junctions with conesSabrina Asteriti0Claudia Gargini1Lorenzo Cangiano2Department of Translational Research, University of Pisa, Pisa, ItalyDepartment of Pharmacy, University of Pisa, Pisa, ItalyDepartment of Translational Research, University of Pisa, Pisa, ItalyRod and cone photoreceptors are coupled by gap junctions (GJs), relatively large channels able to mediate both electrical and molecular communication. Despite their critical location in our visual system and evidence that they are dynamically gated for dark/light adaptation, the full impact that rod–cone GJs can have on cone function is not known. We recorded the photovoltage of mouse cones and found that the initial level of rod input increased spontaneously after obtaining intracellular access. This process allowed us to explore the underlying coupling capacity to rods, revealing that fully coupled cones acquire a striking rod-like phenotype. Calcium, a candidate mediator of the coupling process, does not appear to be involved on the cone side of the junctional channels. Our findings show that the anatomical substrate is adequate for rod–cone coupling to play an important role in vision and, possibly, in biochemical signaling among photoreceptors.https://elifesciences.org/articles/01386photoreceptorgap junctionrodcone |
| spellingShingle | Sabrina Asteriti Claudia Gargini Lorenzo Cangiano Mouse rods signal through gap junctions with cones eLife photoreceptor gap junction rod cone |
| title | Mouse rods signal through gap junctions with cones |
| title_full | Mouse rods signal through gap junctions with cones |
| title_fullStr | Mouse rods signal through gap junctions with cones |
| title_full_unstemmed | Mouse rods signal through gap junctions with cones |
| title_short | Mouse rods signal through gap junctions with cones |
| title_sort | mouse rods signal through gap junctions with cones |
| topic | photoreceptor gap junction rod cone |
| url | https://elifesciences.org/articles/01386 |
| work_keys_str_mv | AT sabrinaasteriti mouserodssignalthroughgapjunctionswithcones AT claudiagargini mouserodssignalthroughgapjunctionswithcones AT lorenzocangiano mouserodssignalthroughgapjunctionswithcones |