Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis

We present a theoretical and numerical study of the bifurcations of the stationary patterns supported by a chemotactic model of Multiple Sclerosis (MS). We derive the normal forms of the dynamics which allows to predict the appearance and stabilization of the emerging branches describing the concen...

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Main Authors: Eleonora Bilotta, Francesco Gargano, Valeria Giunta, Maria Carmela Lombardo, Pietro Pantano, Paolo Falsaperla
Format: Article
Language:English
Published: Accademia Peloritana dei Pericolanti 2018-11-01
Series:Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali
Online Access: http://dx.doi.org/10.1478/AAPP.96S3A9
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author Eleonora Bilotta
Francesco Gargano
Valeria Giunta
Maria Carmela Lombardo
Pietro Pantano
Paolo Falsaperla
author_facet Eleonora Bilotta
Francesco Gargano
Valeria Giunta
Maria Carmela Lombardo
Pietro Pantano
Paolo Falsaperla
author_sort Eleonora Bilotta
collection DOAJ
description We present a theoretical and numerical study of the bifurcations of the stationary patterns supported by a chemotactic model of Multiple Sclerosis (MS). We derive the normal forms of the dynamics which allows to predict the appearance and stabilization of the emerging branches describing the concentric patterns typical of Balo's sclerosis, a very aggressive variant of MS. Spatial modulation of the Turing-type structures through a zigzag instability is also addressed. The nonlinear stage of the Eckhaus and zigzag instability is investigated numerically: defect-mediated wavenumber adjustments are recovered and the time of occurrence of phase-slips is studied as the system parameters are varied.
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spelling doaj.art-f4cf3a36f5164ed696ec89a2bac9e9442022-12-22T01:13:36ZengAccademia Peloritana dei PericolantiAtti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali0365-03591825-12422018-11-0196S3A910.1478/AAPP.96S3A9AAPP.96S3A9Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosisEleonora BilottaFrancesco GarganoValeria GiuntaMaria Carmela LombardoPietro PantanoPaolo FalsaperlaWe present a theoretical and numerical study of the bifurcations of the stationary patterns supported by a chemotactic model of Multiple Sclerosis (MS). We derive the normal forms of the dynamics which allows to predict the appearance and stabilization of the emerging branches describing the concentric patterns typical of Balo's sclerosis, a very aggressive variant of MS. Spatial modulation of the Turing-type structures through a zigzag instability is also addressed. The nonlinear stage of the Eckhaus and zigzag instability is investigated numerically: defect-mediated wavenumber adjustments are recovered and the time of occurrence of phase-slips is studied as the system parameters are varied. http://dx.doi.org/10.1478/AAPP.96S3A9
spellingShingle Eleonora Bilotta
Francesco Gargano
Valeria Giunta
Maria Carmela Lombardo
Pietro Pantano
Paolo Falsaperla
Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali
title Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
title_full Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
title_fullStr Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
title_full_unstemmed Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
title_short Eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
title_sort eckhaus and zigzag instability in a chemotaxis model of multiple sclerosis
url http://dx.doi.org/10.1478/AAPP.96S3A9
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