Macrophage Function and the Role of GSK3
Macrophages are present in nearly all vertebrate tissues, where they respond to a complex variety of regulatory signals to coordinate immune functions involved in tissue development, metabolism, homeostasis, and repair. Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed protein kinase tha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/2206 |
| _version_ | 1797395611434090496 |
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| author | Sarvatit Patel Geoff H. Werstuck |
| author_facet | Sarvatit Patel Geoff H. Werstuck |
| author_sort | Sarvatit Patel |
| collection | DOAJ |
| description | Macrophages are present in nearly all vertebrate tissues, where they respond to a complex variety of regulatory signals to coordinate immune functions involved in tissue development, metabolism, homeostasis, and repair. Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed protein kinase that plays important roles in multiple pathways involved in cell metabolism. Dysregulation of GSK3 has been implicated in several prevalent metabolic disorders, and recent findings have highlighted the importance of GSK3 activity in the regulation of macrophages, especially with respect to the initiation of specific pathologies. This makes GSK3 a potential therapeutic target for the development of novel drugs to modulate immunometabolic responses. Here, we summarize recent findings that have contributed to our understanding of how GSK3 regulates macrophage function, and we discuss the role of GSK3 in the development of metabolic disorders and diseases. |
| first_indexed | 2024-03-09T00:37:01Z |
| format | Article |
| id | doaj.art-f4d084930ab44d77976af86c445f8585 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T00:37:01Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4d084930ab44d77976af86c445f85852023-12-11T18:06:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224220610.3390/ijms22042206Macrophage Function and the Role of GSK3Sarvatit Patel0Geoff H. Werstuck1Thrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, CanadaThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, CanadaMacrophages are present in nearly all vertebrate tissues, where they respond to a complex variety of regulatory signals to coordinate immune functions involved in tissue development, metabolism, homeostasis, and repair. Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed protein kinase that plays important roles in multiple pathways involved in cell metabolism. Dysregulation of GSK3 has been implicated in several prevalent metabolic disorders, and recent findings have highlighted the importance of GSK3 activity in the regulation of macrophages, especially with respect to the initiation of specific pathologies. This makes GSK3 a potential therapeutic target for the development of novel drugs to modulate immunometabolic responses. Here, we summarize recent findings that have contributed to our understanding of how GSK3 regulates macrophage function, and we discuss the role of GSK3 in the development of metabolic disorders and diseases.https://www.mdpi.com/1422-0067/22/4/2206macrophage functionglycogen synthase kinase (GSK)-3molecular mechanismsinflammatory responseatherosclerosis |
| spellingShingle | Sarvatit Patel Geoff H. Werstuck Macrophage Function and the Role of GSK3 International Journal of Molecular Sciences macrophage function glycogen synthase kinase (GSK)-3 molecular mechanisms inflammatory response atherosclerosis |
| title | Macrophage Function and the Role of GSK3 |
| title_full | Macrophage Function and the Role of GSK3 |
| title_fullStr | Macrophage Function and the Role of GSK3 |
| title_full_unstemmed | Macrophage Function and the Role of GSK3 |
| title_short | Macrophage Function and the Role of GSK3 |
| title_sort | macrophage function and the role of gsk3 |
| topic | macrophage function glycogen synthase kinase (GSK)-3 molecular mechanisms inflammatory response atherosclerosis |
| url | https://www.mdpi.com/1422-0067/22/4/2206 |
| work_keys_str_mv | AT sarvatitpatel macrophagefunctionandtheroleofgsk3 AT geoffhwerstuck macrophagefunctionandtheroleofgsk3 |