Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2018-12-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861318302032 |
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author | Kosuke Kitahata Kazuhiko Matsuo Yuta Hara Takanori Naganuma Naoki Oiso Akira Kawada Takashi Nakayama |
author_facet | Kosuke Kitahata Kazuhiko Matsuo Yuta Hara Takanori Naganuma Naoki Oiso Akira Kawada Takashi Nakayama |
author_sort | Kosuke Kitahata |
collection | DOAJ |
description | Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis. Keywords: Ascorbic acid derivative, Psoriasis, Inflammatory cytokine |
first_indexed | 2024-12-10T05:35:28Z |
format | Article |
id | doaj.art-f4d11687e79a425fb42f420d6dc5c6c4 |
institution | Directory Open Access Journal |
issn | 1347-8613 |
language | English |
last_indexed | 2024-12-10T05:35:28Z |
publishDate | 2018-12-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Pharmacological Sciences |
spelling | doaj.art-f4d11687e79a425fb42f420d6dc5c6c42022-12-22T02:00:26ZengElsevierJournal of Pharmacological Sciences1347-86132018-12-011384284288Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expressionKosuke Kitahata0Kazuhiko Matsuo1Yuta Hara2Takanori Naganuma3Naoki Oiso4Akira Kawada5Takashi Nakayama6Division of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanLaboratory of Cell Biology, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDepartment of Dermatology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osaka-sayama, Osaka, JapanDepartment of Dermatology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osaka-sayama, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, Japan; Corresponding author. Fax: +81 6 6730 1394.Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis. Keywords: Ascorbic acid derivative, Psoriasis, Inflammatory cytokinehttp://www.sciencedirect.com/science/article/pii/S1347861318302032 |
spellingShingle | Kosuke Kitahata Kazuhiko Matsuo Yuta Hara Takanori Naganuma Naoki Oiso Akira Kawada Takashi Nakayama Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression Journal of Pharmacological Sciences |
title | Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression |
title_full | Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression |
title_fullStr | Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression |
title_full_unstemmed | Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression |
title_short | Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression |
title_sort | ascorbic acid derivative ddh 1 ameliorates psoriasis like skin lesions in mice by suppressing inflammatory cytokine expression |
url | http://www.sciencedirect.com/science/article/pii/S1347861318302032 |
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