Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression

Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its...

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Main Authors: Kosuke Kitahata, Kazuhiko Matsuo, Yuta Hara, Takanori Naganuma, Naoki Oiso, Akira Kawada, Takashi Nakayama
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318302032
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author Kosuke Kitahata
Kazuhiko Matsuo
Yuta Hara
Takanori Naganuma
Naoki Oiso
Akira Kawada
Takashi Nakayama
author_facet Kosuke Kitahata
Kazuhiko Matsuo
Yuta Hara
Takanori Naganuma
Naoki Oiso
Akira Kawada
Takashi Nakayama
author_sort Kosuke Kitahata
collection DOAJ
description Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis. Keywords: Ascorbic acid derivative, Psoriasis, Inflammatory cytokine
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spelling doaj.art-f4d11687e79a425fb42f420d6dc5c6c42022-12-22T02:00:26ZengElsevierJournal of Pharmacological Sciences1347-86132018-12-011384284288Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expressionKosuke Kitahata0Kazuhiko Matsuo1Yuta Hara2Takanori Naganuma3Naoki Oiso4Akira Kawada5Takashi Nakayama6Division of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanLaboratory of Cell Biology, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, JapanDepartment of Dermatology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osaka-sayama, Osaka, JapanDepartment of Dermatology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osaka-sayama, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, Japan; Corresponding author. Fax: +81 6 6730 1394.Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis. Keywords: Ascorbic acid derivative, Psoriasis, Inflammatory cytokinehttp://www.sciencedirect.com/science/article/pii/S1347861318302032
spellingShingle Kosuke Kitahata
Kazuhiko Matsuo
Yuta Hara
Takanori Naganuma
Naoki Oiso
Akira Kawada
Takashi Nakayama
Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
Journal of Pharmacological Sciences
title Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
title_full Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
title_fullStr Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
title_full_unstemmed Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
title_short Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression
title_sort ascorbic acid derivative ddh 1 ameliorates psoriasis like skin lesions in mice by suppressing inflammatory cytokine expression
url http://www.sciencedirect.com/science/article/pii/S1347861318302032
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