MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets
The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in differen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.764025/full |
| _version_ | 1819031222803759104 |
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| author | Bashdar Mahmud Hussen Sara Tharwat Abdullah Mohammed Fatih Rasul Abbas Salihi Abbas Salihi Soudeh Ghafouri-Fard Hazha Jamal Hidayat Mohammad Taheri Mohammad Taheri |
| author_facet | Bashdar Mahmud Hussen Sara Tharwat Abdullah Mohammed Fatih Rasul Abbas Salihi Abbas Salihi Soudeh Ghafouri-Fard Hazha Jamal Hidayat Mohammad Taheri Mohammad Taheri |
| author_sort | Bashdar Mahmud Hussen |
| collection | DOAJ |
| description | The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response. |
| first_indexed | 2024-12-21T06:42:37Z |
| format | Article |
| id | doaj.art-f4d15f85a44c40368c1c1627b89b8057 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-21T06:42:37Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-f4d15f85a44c40368c1c1627b89b80572022-12-21T19:12:41ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-10-01810.3389/fmolb.2021.764025764025MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic TargetsBashdar Mahmud Hussen0Sara Tharwat Abdullah1Mohammed Fatih Rasul2Abbas Salihi3Abbas Salihi4Soudeh Ghafouri-Fard5Hazha Jamal Hidayat6Mohammad Taheri7Mohammad Taheri8Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqDepartment of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, IraqDepartment of Medical Analysis, Faculty of Science, Tishk International University-Erbil, Erbil, IraqDepartment of Biology, College of Science, Salahaddin University-Erbil, Erbil, IraqCenter of Research and Strategic Studies, Lebanese French University, Erbil, IraqDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Biology, College of Education, Salahaddin University-Erbil, Erbil, IraqSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInstitute of Human Genetics, Jena University Hospital, Jena, GermanyThe high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.https://www.frontiersin.org/articles/10.3389/fmolb.2021.764025/fullbreast cancermicroRNAvascular endothelial growth factorangiogenesistherapeutic target 3 |
| spellingShingle | Bashdar Mahmud Hussen Sara Tharwat Abdullah Mohammed Fatih Rasul Abbas Salihi Abbas Salihi Soudeh Ghafouri-Fard Hazha Jamal Hidayat Mohammad Taheri Mohammad Taheri MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets Frontiers in Molecular Biosciences breast cancer microRNA vascular endothelial growth factor angiogenesis therapeutic target 3 |
| title | MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets |
| title_full | MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets |
| title_fullStr | MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets |
| title_full_unstemmed | MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets |
| title_short | MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets |
| title_sort | micrornas important players in breast cancer angiogenesis and therapeutic targets |
| topic | breast cancer microRNA vascular endothelial growth factor angiogenesis therapeutic target 3 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.764025/full |
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