Anti-Inflammatory Drugs as Anticancer Agents
Inflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could repre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2605 |
| _version_ | 1797571161511428096 |
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| author | Silvia Zappavigna Alessia Maria Cossu Anna Grimaldi Marco Bocchetti Giuseppe Andrea Ferraro Giovanni Francesco Nicoletti Rosanna Filosa Michele Caraglia |
| author_facet | Silvia Zappavigna Alessia Maria Cossu Anna Grimaldi Marco Bocchetti Giuseppe Andrea Ferraro Giovanni Francesco Nicoletti Rosanna Filosa Michele Caraglia |
| author_sort | Silvia Zappavigna |
| collection | DOAJ |
| description | Inflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could represent a good strategy for cancer prevention and therapy. In the past, several clinical studies have demonstrated that many anti-inflammatory agents, including non-steroidal anti-inflammatory drugs (NSAIDs), are able to interfere with the tumor microenvironment by reducing cell migration and increasing apoptosis and chemo-sensitivity. This review focuses on the link between inflammation and cancer by describing the anti-inflammatory agents used in cancer therapy, and their mechanisms of action, emphasizing the use of novel anti-inflammatory agents with significant anticancer activity. |
| first_indexed | 2024-03-10T20:35:25Z |
| format | Article |
| id | doaj.art-f4d2573a4c51405ab30e0b48581329ed |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:35:25Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4d2573a4c51405ab30e0b48581329ed2023-11-19T21:06:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217260510.3390/ijms21072605Anti-Inflammatory Drugs as Anticancer AgentsSilvia Zappavigna0Alessia Maria Cossu1Anna Grimaldi2Marco Bocchetti3Giuseppe Andrea Ferraro4Giovanni Francesco Nicoletti5Rosanna Filosa6Michele Caraglia7Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMultidisciplinary Department of Medical and Dental Specialties, University of Campania, “Luigi Vanvitelli”, Plastic Surgery Unit, 80138 Naples, ItalyMultidisciplinary Department of Medical and Dental Specialties, University of Campania, “Luigi Vanvitelli”, Plastic Surgery Unit, 80138 Naples, ItalyDepartment of Science and Technology, University of Sannio, 82100 Benevento, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyInflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could represent a good strategy for cancer prevention and therapy. In the past, several clinical studies have demonstrated that many anti-inflammatory agents, including non-steroidal anti-inflammatory drugs (NSAIDs), are able to interfere with the tumor microenvironment by reducing cell migration and increasing apoptosis and chemo-sensitivity. This review focuses on the link between inflammation and cancer by describing the anti-inflammatory agents used in cancer therapy, and their mechanisms of action, emphasizing the use of novel anti-inflammatory agents with significant anticancer activity.https://www.mdpi.com/1422-0067/21/7/2605cancerCOX-2 inhibitorsembelininflammation-associated cancer5-LOX inhibitorsNSAIDs |
| spellingShingle | Silvia Zappavigna Alessia Maria Cossu Anna Grimaldi Marco Bocchetti Giuseppe Andrea Ferraro Giovanni Francesco Nicoletti Rosanna Filosa Michele Caraglia Anti-Inflammatory Drugs as Anticancer Agents International Journal of Molecular Sciences cancer COX-2 inhibitors embelin inflammation-associated cancer 5-LOX inhibitors NSAIDs |
| title | Anti-Inflammatory Drugs as Anticancer Agents |
| title_full | Anti-Inflammatory Drugs as Anticancer Agents |
| title_fullStr | Anti-Inflammatory Drugs as Anticancer Agents |
| title_full_unstemmed | Anti-Inflammatory Drugs as Anticancer Agents |
| title_short | Anti-Inflammatory Drugs as Anticancer Agents |
| title_sort | anti inflammatory drugs as anticancer agents |
| topic | cancer COX-2 inhibitors embelin inflammation-associated cancer 5-LOX inhibitors NSAIDs |
| url | https://www.mdpi.com/1422-0067/21/7/2605 |
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