Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts
Transition-metal-free direct arylation of C-H or N-H bonds is one of the key emerging methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve as a stepping stone on the way to alternative environmentally friendly and straightforward pathways for the construction o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/7/661 |
| _version_ | 1797526424088739840 |
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| author | Thierry Besson Corinne Fruit |
| author_facet | Thierry Besson Corinne Fruit |
| author_sort | Thierry Besson |
| collection | DOAJ |
| description | Transition-metal-free direct arylation of C-H or N-H bonds is one of the key emerging methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve as a stepping stone on the way to alternative environmentally friendly and straightforward pathways for the construction of C-C and C-heteroatom bonds. In this review, we emphasize the recent synthetic advances of late-stage C(sp2)-N and C(sp2)-C(sp2) bond-forming reactions under metal-free conditions using diaryliodonium salts as arylating reagent and its applications to the synthesis of new arylated bioactive heterocyclic compounds. |
| first_indexed | 2024-03-10T09:29:06Z |
| format | Article |
| id | doaj.art-f4d27dca493e47c38a1ec2338b8d04bb |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T09:29:06Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f4d27dca493e47c38a1ec2338b8d04bb2023-11-22T04:39:47ZengMDPI AGPharmaceuticals1424-82472021-07-0114766110.3390/ph14070661Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium SaltsThierry Besson0Corinne Fruit1Normandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, F-76000 Rouen, FranceNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, F-76000 Rouen, FranceTransition-metal-free direct arylation of C-H or N-H bonds is one of the key emerging methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve as a stepping stone on the way to alternative environmentally friendly and straightforward pathways for the construction of C-C and C-heteroatom bonds. In this review, we emphasize the recent synthetic advances of late-stage C(sp2)-N and C(sp2)-C(sp2) bond-forming reactions under metal-free conditions using diaryliodonium salts as arylating reagent and its applications to the synthesis of new arylated bioactive heterocyclic compounds.https://www.mdpi.com/1424-8247/14/7/661diaryliodonium saltsC-H arylation<i>N</i>-arylationheteroarenesmetal-freelate-stage functionalization |
| spellingShingle | Thierry Besson Corinne Fruit Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts Pharmaceuticals diaryliodonium salts C-H arylation <i>N</i>-arylation heteroarenes metal-free late-stage functionalization |
| title | Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts |
| title_full | Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts |
| title_fullStr | Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts |
| title_full_unstemmed | Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts |
| title_short | Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts |
| title_sort | recent advances in transition metal free late stage c h and n h arylation of heteroarenes using diaryliodonium salts |
| topic | diaryliodonium salts C-H arylation <i>N</i>-arylation heteroarenes metal-free late-stage functionalization |
| url | https://www.mdpi.com/1424-8247/14/7/661 |
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